Literature DB >> 17317692

Regulation of Wnt signalling by receptor-mediated endocytosis.

Akira Kikuchi1, Hideki Yamamoto.   

Abstract

Wnts compromise a large family of secreted and hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms. Recent advances in the field of Wnt signalling have revealed that Wnt activates multiple intracellular cascades, resulting in the regulation of cellular proliferation, differentiation, migration and polarity. However, it is not clear how Wnt activates these pathways after it binds to the receptors. It has been shown that Wnt and its antagonist Dickkopf are internalized with their receptors. This review highlights distinct endocytic pathways correlate with specificity of Wnt signalling events.

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Year:  2007        PMID： 17317692     DOI： 10.1093/jb/mvm061

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  16 in total

Review 1.  beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

Authors:  Gunnar Schulte; Alexandra Schambony; Vítezslav Bryja
Journal:  Br J Pharmacol       Date:  2009-11-03       Impact factor: 8.739

2.  Multi-scale modeling of APC and [Formula: see text]-catenin regulation in the human colonic crypt.

Authors:  Brooks Emerick; Gilberto Schleiniger; Bruce M Boman
Journal:  J Math Biol       Date:  2018-01-04       Impact factor: 2.259

3.  A kinetic model to study the regulation of β-catenin, APC, and Axin in the human colonic crypt.

Authors:  Brooks Emerick; Gilberto Schleiniger; Bruce M Boman
Journal:  J Math Biol       Date:  2017-03-07       Impact factor: 2.259

4.  The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.

Authors:  Jennie Lugassy; Shelly Zaffryar-Eilot; Sharon Soueid; Amit Mordoviz; Victoria Smith; Ofra Kessler; Gera Neufeld
Journal:  J Biol Chem       Date:  2011-12-08       Impact factor: 5.157

5.  LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

Authors:  Andrei Glinka; Christine Dolde; Nadine Kirsch; Ya-Lin Huang; Olga Kazanskaya; Dierk Ingelfinger; Michael Boutros; Cristina-Maria Cruciat; Christof Niehrs
Journal:  EMBO Rep       Date:  2011-09-30       Impact factor: 8.807

6.  Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt.

Authors:  Akiko Mukai; Miki Yamamoto-Hino; Wakae Awano; Wakako Watanabe; Masayuki Komada; Satoshi Goto
Journal:  EMBO J       Date:  2010-05-21       Impact factor: 11.598

7.  Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements.

Authors:  Gun-Hwa Kim; Jung-Hyun Her; Jin-Kwan Han
Journal:  J Cell Biol       Date:  2008-09-22       Impact factor: 10.539

8.  High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.

Authors:  Sanjay K Mishra; Lacey Funair; Alex Cressley; George K Gittes; R Cartland Burns
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240

9.  Wnt/β-catenin signaling in heart regeneration.

Authors:  Gunes Ozhan; Gilbert Weidinger
Journal:  Cell Regen (Lond)       Date:  2015-07-08

10.  hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma.

Authors:  Ling Liu; Feng Ding; Jiwei Chen; Boyong Wang; Zhisu Liu
Journal:  Oncol Lett       Date:  2014-02-03       Impact factor: 2.967
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