Literature DB >> 17317185

CRM1-mediated nuclear export: to the pore and beyond.

Saskia Hutten1, Ralph H Kehlenbach.   

Abstract

CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell.

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Year:  2007        PMID： 17317185     DOI： 10.1016/j.tcb.2007.02.003

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  164 in total

1.  The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export.

Authors:  Mark Hilliard; Cornelia Frohnert; Christiane Spillner; Simone Marcone; Annegret Nath; Tina Lampe; Desmond J Fitzgerald; Ralph H Kehlenbach
Journal:  J Biol Chem       Date:  2010-05-10       Impact factor: 5.157

2.  CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts.

Authors:  Melanie Schmid; Ramon A Gonzalez; Thomas Dobner
Journal:  J Virol       Date:  2011-12-14       Impact factor: 5.103

3.  Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

Authors:  Heiko Dückert; Verena Pries; Vivek Khedkar; Sascha Menninger; Hanna Bruss; Alexander W Bird; Zoltan Maliga; Andreas Brockmeyer; Petra Janning; Anthony Hyman; Stefan Grimme; Markus Schürmann; Hans Preut; Katja Hübel; Slava Ziegler; Kamal Kumar; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2011-12-25       Impact factor: 15.040

4.  Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins.

Authors:  Akiko Takeda; Nayan J Sarma; Anmaar M Abdul-Nabi; Nabeel R Yaseen
Journal:  J Biol Chem       Date:  2010-03-16       Impact factor: 5.157

5.  Nucleocytoplasmic distribution is required for activation of resistance by the potato NB-LRR receptor Rx1 and is balanced by its functional domains.

Authors:  Erik Slootweg; Jan Roosien; Laurentiu N Spiridon; Andrei-Jose Petrescu; Wladimir Tameling; Matthieu Joosten; Rikus Pomp; Casper van Schaik; Robert Dees; Jan Willem Borst; Geert Smant; Arjen Schots; Jaap Bakker; Aska Goverse
Journal:  Plant Cell       Date:  2010-12-21       Impact factor: 11.277

6.  Revisiting an old acquaintance: role for eIF5A in diabetes.

Authors:  Joachim Hauber
Journal:  J Clin Invest       Date:  2010-05-24       Impact factor: 14.808

7.  2p15-p16.1 microdeletion syndrome: molecular characterization and association of the OTX1 and XPO1 genes with autism spectrum disorders.

Authors:  Xudong Liu; Patrick Malenfant; Chelsea Reesor; Alana Lee; Melissa L Hudson; Chansonette Harvard; Ying Qiao; Antonio M Persico; Ira L Cohen; Albert E Chudley; Cynthia Forster-Gibson; Evica Rajcan-Separovic; M E Suzanne Lewis; Jeanette J A Holden
Journal:  Eur J Hum Genet       Date:  2011-07-13       Impact factor: 4.246

Review 8.  Aiding and abetting cancer: mRNA export and the nuclear pore.

Authors:  Biljana Culjkovic-Kraljacic; Katherine L B Borden
Journal:  Trends Cell Biol       Date:  2013-04-10       Impact factor: 20.808

Review 9.  Postage for the messenger: designating routes for nuclear mRNA export.

Authors:  Barbara J Natalizio; Susan R Wente
Journal:  Trends Cell Biol       Date:  2013-04-11       Impact factor: 20.808

10.  Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry.

Authors:  Ketan Thakar; Samir Karaca; Sarah A Port; Henning Urlaub; Ralph H Kehlenbach
Journal:  Mol Cell Proteomics       Date:  2012-12-13       Impact factor: 5.911
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