Literature DB >> 17317182

Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1).

Shenlin Huang1, Ronghua Li, Peter J Connolly, Stuart Emanuel, Angel Fuentes-Pesquera, Mary Adams, Robert H Gruninger, Jabed Seraj, Steven A Middleton, Jeremy M Davis, David F C Moffat.   

Abstract

The series of 2-amino-4-aryl-5-chloropyrimidines was discovered to be potent for both VEGFR-2 and CDK1. Described here are the chemistry for analogue synthesis, SAR study, and its kinase selectivity prolifing. The full rat PK data and in vivo efficacy study are also included.

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Year:  2007        PMID： 17317182     DOI： 10.1016/j.bmcl.2007.01.086

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity.

Authors:  Gabriel E Büchel; Iryna N Stepanenko; Michaela Hejl; Michael A Jakupec; Bernhard K Keppler; Petra Heffeter; Walter Berger; Vladimir B Arion
Journal:  J Inorg Biochem       Date:  2012-04-10       Impact factor: 4.155

2.  In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Authors:  Antony M Latham; Jayakanth Kankanala; Gareth W Fearnley; Matthew C Gage; Mark T Kearney; Shervanthi Homer-Vanniasinkam; Stephen B Wheatcroft; Colin W G Fishwick; Sreenivasan Ponnambalam
Journal:  PLoS One       Date:  2014-11-13       Impact factor: 3.240
  2 in total

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