| Literature DB >> 17316920 |
Patrick Angibaud1, Laurence Mevellec, Christophe Meyer, Xavier Bourdrez, Patricia Lezouret, Isabelle Pilatte, Virginie Poncelet, Bruno Roux, Sophie Merillon, David W End, Jacky Van Dun, Walter Wouters, Marc Venet.
Abstract
Based on the structure of R115777 (tipifarnib, Zarnestra), a series of farnesyltransferase inhibitors have been synthesized by modification of the 2-quinolinone motif and transposition of the 4-chlorophenyl ring to the imidazole or its replacement by 5-membered rings. This has yielded a novel series of potent farnesyltransferase inhibitors.Entities:
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Year: 2007 PMID： 17316920 DOI： 10.1016/j.ejmech.2006.12.007
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514