Literature DB >> 17316560

The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?

John Golin1, Suresh V Ambudkar, Leopold May.   

Abstract

Multidrug transporters are of considerable importance because they present problems in the treatment of infectious disease and cancer. A central issue is the ability of efflux pumps to recognize an astounding array of structurally diverse compounds. The yeast Pdr5p efflux pump, which is a member of the ATP-binding cassette superfamily, has at least 3 substrate-binding sites, each of which appears to use different chemical properties to transport compounds. All Pdr5p substrates, however, have a size requirement that is independent of hydrophobicity.

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Year:  2007        PMID： 17316560     DOI： 10.1016/j.bbrc.2007.02.011

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Authors:  Neeti Ananthaswamy; Robert Rutledge; Zuben E Sauna; Suresh V Ambudkar; Elliot Dine; Emily Nelson; Di Xia; John Golin
Journal:  Biochemistry       Date:  2010-06-01       Impact factor: 3.162

2.  Evidence for a molecular diode-based mechanism in a multispecific ATP-binding cassette (ABC) exporter: SER-1368 as a gatekeeping residue in the yeast multidrug transporter Pdr5.

Authors:  Jitender Mehla; Robert Ernst; Rachel Moore; Adina Wakschlag; Mary Kate Marquis; Suresh V Ambudkar; John Golin
Journal:  J Biol Chem       Date:  2014-08-11       Impact factor: 5.157

3.  A member of the PLEIOTROPIC DRUG RESISTANCE family of ATP binding cassette transporters is required for the formation of a functional cuticle in Arabidopsis.

Authors:  Michael Bessire; Sandra Borel; Guillaume Fabre; Luis Carraça; Nadia Efremova; Alexander Yephremov; Yan Cao; Reinhard Jetter; Anne-Claude Jacquat; Jean-Pierre Métraux; Christiane Nawrath
Journal:  Plant Cell       Date:  2011-05-31       Impact factor: 11.277

4.  Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.

Authors:  Manpreet Kaur Rawal; Mohammad Firoz Khan; Khyati Kapoor; Neha Goyal; Sobhan Sen; Ajay Kumar Saxena; Andrew M Lynn; Joel D A Tyndall; Brian C Monk; Richard D Cannon; Sneha Sudha Komath; Rajendra Prasad
Journal:  J Biol Chem       Date:  2013-07-03       Impact factor: 5.157

5.  Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen.

Authors:  Wenjun Guan; Huifeng Jiang; Xiaoxian Guo; Eugenio Mancera; Lin Xu; Yudong Li; Lars Steinmetz; Yongquan Li; Zhenglong Gu
Journal:  PLoS One       Date:  2010-06-25       Impact factor: 3.240

6.  A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.

Authors:  Robert Ernst; Petra Kueppers; Cornelia M Klein; Tobias Schwarzmueller; Karl Kuchler; Lutz Schmitt
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-20       Impact factor: 11.205

7.  Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.

Authors:  Zuben E Sauna; Sherry Supernavage Bohn; Robert Rutledge; Michael P Dougherty; Susan Cronin; Leopold May; Di Xia; Suresh V Ambudkar; John Golin
Journal:  J Biol Chem       Date:  2008-10-08       Impact factor: 5.157

Review 8.  Efflux-mediated antifungal drug resistance.

Authors:  Richard D Cannon; Erwin Lamping; Ann R Holmes; Kyoko Niimi; Philippe V Baret; Mikhail V Keniya; Koichi Tanabe; Masakazu Niimi; Andre Goffeau; Brian C Monk
Journal:  Clin Microbiol Rev       Date:  2009-04       Impact factor: 26.132

9.  Generating symmetry in the asymmetric ATP-binding cassette (ABC) transporter Pdr5 from Saccharomyces cerevisiae.

Authors:  Rakeshkumar P Gupta; Petra Kueppers; Nils Hanekop; Lutz Schmitt
Journal:  J Biol Chem       Date:  2014-04-14       Impact factor: 5.157

10.  Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts.

Authors:  Marie-Line Seret; Julie F Diffels; André Goffeau; Philippe V Baret
Journal:  BMC Genomics       Date:  2009-10-01       Impact factor: 3.969
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