Literature DB >> 17316046

A short, efficient, and stereoselective total synthesis of a pyrrolidine alkaloid: (-)-codonopsinine.

Jangari Santhosh Reddy1, Batchu Venkateswara Rao.   

Abstract

An efficient total synthesis of antibiotic (-)-codonopsinine 1 with an overall yield of 44% was achieved from d-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly stereoselective intramolecular acid-catalyzed amidocyclization.

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Year:  2007        PMID: 17316046     DOI: 10.1021/jo061940q

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem-catalyzed pyrrole synthesis.

Authors:  Minami Yamaguchi; Daichi Itagaki; Hirofumi Ueda; Hidetoshi Tokuyama
Journal:  J Antibiot (Tokyo)       Date:  2016-02-17       Impact factor: 2.649

2.  In vitro inhibitory and cytotoxic activity of MFM 501, a novel codonopsinine derivative, against Methicillin-Resistant Staphylococcus aureus clinical isolates.

Authors:  Saiful Azmi Johari; Mastura Mohtar; Sharifah Aminah Syed Mohammad; Rohana Sahdan; Zurina Shaameri; Ahmad Sazali Hamzah; Mohd Fazli Mohammat
Journal:  Biomed Res Int       Date:  2015-02-01       Impact factor: 3.411

  2 in total

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