| Literature DB >> 17314996 |
M L Sales, M C S Ferreira, C A Leme, L A Velloso, M C J Gallani, R C R Colombo, K G Franchini, W Nadruz.
Abstract
The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system. The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension. We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy.Entities:
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Year: 2007 PMID： 17314996 DOI： 10.1038/sj.jhh.1002170
Source DB: PubMed Journal: J Hum Hypertens ISSN： 0950-9240 Impact factor: 3.012