Literature DB >> 17314528

HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.

Susan Jung1, Melanie Eichenmüller, Norbert Donhauser, Frank Neipel, Alfred M Engel, Georg Hess, Bernhard Fleckenstein, Heide Reil.   

Abstract

Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.

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Year:  2007        PMID： 17314528     DOI： 10.1097/QAD.0b013e32803277c7

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  27 in total

1.  Characterization of a peptide domain within the GB virus C envelope glycoprotein (E2) that inhibits HIV replication.

Authors:  Jinhua Xiang; James H McLinden; Thomas M Kaufman; Emma L Mohr; Nirjal Bhattarai; Qing Chang; Jack T Stapleton
Journal:  Virology       Date:  2012-05-16       Impact factor: 3.616

Review 2.  Role of GB virus C in modulating HIV disease.

Authors:  Carolynne Schwarze-Zander; Jason T Blackard; Juergen K Rockstroh
Journal:  Expert Rev Anti Infect Ther       Date:  2012-05       Impact factor: 5.091

3.  Deep sequencing identifies two genotypes and high viral genetic diversity of human pegivirus (GB virus C) in rural Ugandan patients.

Authors:  Ria R Ghai; Samuel D Sibley; Michael Lauck; Jorge M Dinis; Adam L Bailey; Colin A Chapman; Patrick Omeja; Thomas C Friedrich; David H O'Connor; Tony L Goldberg
Journal:  J Gen Virol       Date:  2013-09-28       Impact factor: 3.891

4.  Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge.

Authors:  Delphine C Malherbe; Jason Mendy; Lo Vang; Philip T Barnette; Jason Reed; Samir K Lakhashe; Joshua Owuor; Johannes S Gach; Alfred W Legasse; Michael K Axthelm; Celia C LaBranche; David Montefiori; Donald N Forthal; Byung Park; James M Wilson; James H McLinden; Jinhua Xiang; Jack T Stapleton; Jonah B Sacha; Barton F Haynes; Hua-Xin Liao; Ruth M Ruprecht; Jonathan Smith; Marc Gurwith; Nancy L Haigwood; Jeff Alexander
Journal:  J Virol       Date:  2018-01-02       Impact factor: 5.103

5.  Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.

Authors:  Yvonne Koedel; Kristin Eissmann; Holger Wend; Bernhard Fleckenstein; Heide Reil
Journal:  J Virol       Date:  2011-05-04       Impact factor: 5.103

6.  GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways.

Authors:  Nirjal Bhattarai; James H McLinden; Jinhua Xiang; Thomas M Kaufman; Jack T Stapleton
Journal:  J Immunol       Date:  2012-07-27       Impact factor: 5.422

7.  Viruses within the Flaviviridae decrease CD4 expression and inhibit HIV replication in human CD4+ cells.

Authors:  Jinhua Xiang; James H McLinden; Robert A Rydze; Qing Chang; Thomas M Kaufman; Donna Klinzman; Jack T Stapleton
Journal:  J Immunol       Date:  2009-12-15       Impact factor: 5.422

8.  Chimpanzee GB virus C and GB virus A E2 envelope glycoproteins contain a peptide motif that inhibits human immunodeficiency virus type 1 replication in human CD4⁺ T-cells.

Authors:  James H McLinden; Jack T Stapleton; Donna Klinzman; Krishna K Murthy; Qing Chang; Thomas M Kaufman; Nirjal Bhattarai; Jinhua Xiang
Journal:  J Gen Virol       Date:  2013-01-03       Impact factor: 3.891

9.  Role of GB virus C in HIV-1-infected and hepatitis C virus-infected hemophiliac children and adolescents.

Authors:  Solveig Tenckhoff; Thorsten Kaiser; Fritz Bredeek; Sharyne Donfield; Erika Menius; Alice Lail; Joachim Mössner; Eric S Daar; Hans L Tillmann
Journal:  J Acquir Immune Defic Syndr       Date:  2012-10-01       Impact factor: 3.731

Review 10.  GB virus type C interactions with HIV: the role of envelope glycoproteins.

Authors:  Emma L Mohr; Jack T Stapleton
Journal:  J Viral Hepat       Date:  2009-09-15       Impact factor: 3.728
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