Oliver Stich1, Barbara Kleer, Sebastian Rauer. 1. Neurologische Klinik und Poliklinik der Albert-Ludwigs-Universitaet Freiburg, Breisacher Strasse 64, D-79106 Freiburg, Germany.
Abstract
BACKGROUND: Well characterised antineuronal antibodies (ANAbs) have been shown to be highly specific markers of neurological syndromes with a paraneoplastic aetiology. Previous reports indicate that pure motor neuron disease (MND) is rarely of paraneoplastic origin. OBJECTIVE: To screen systematically for the prevalence of well characterised paraneoplastic ANAbs in a large collective of patients with pure MND. METHODS: In a cohort of 145 patients with MND, the frequency of ANAbs was estimated by ELISA, employing recombinant antigens (HuD, Yo, Ri, CV2/CRMP5, Ma2 and amphiphysin). RESULTS: None of the sera revealed high antineuronal antigen reactivity. Very low reactivity was detected in only five sera, in all probability representing background activity. CONCLUSION: According to these data, routine analysis for ANAbs in patients with isolated MND is not mandatory.
BACKGROUND: Well characterised antineuronal antibodies (ANAbs) have been shown to be highly specific markers of neurological syndromes with a paraneoplastic aetiology. Previous reports indicate that pure motor neuron disease (MND) is rarely of paraneoplastic origin. OBJECTIVE: To screen systematically for the prevalence of well characterised paraneoplasticANAbs in a large collective of patients with pure MND. METHODS: In a cohort of 145 patients with MND, the frequency of ANAbs was estimated by ELISA, employing recombinant antigens (HuD, Yo, Ri, CV2/CRMP5, Ma2 and amphiphysin). RESULTS: None of the sera revealed high antineuronal antigen reactivity. Very low reactivity was detected in only five sera, in all probability representing background activity. CONCLUSION: According to these data, routine analysis for ANAbs in patients with isolated MND is not mandatory.
Authors: F Graus; J Y Delattre; J C Antoine; J Dalmau; B Giometto; W Grisold; J Honnorat; P Sillevis Smitt; Ch Vedeler; J J G M Verschuuren; A Vincent; R Voltz Journal: J Neurol Neurosurg Psychiatry Date: 2004-08 Impact factor: 10.154
Authors: M Vianello; R Vitaliani; R Pezzani; P Nicolao; C Betterle; G Keir; E J Thompson; B Tavolato; F Scaravilli; B Giometto Journal: J Neurol Sci Date: 2004-05-15 Impact factor: 3.181