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Literature DB >> 17314051

The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract.

Alberto J Núñez-Sellés¹, René Delgado-Hernández, Gabino Garrido-Garrido, Dagmar García-Rivera, Mariela Guevara-García, Gilberto L Pardo-Andreu.

Abstract

Recent findings regarding basic, pre-clinical and clinical studies on a mango stem bark extract (MSBE) developed in Cuba (Vimang) on an industrial scale are summarized. Ethnomedical studies, extract reproducibility, biological effects and clinical evaluations in terms of patient quality of life are described as experimental evidences to support the statement that natural products, even being a mixture of compounds, could be as effective as "monoceuticals" for medical uses. Discussion about the use of "monoceuticals" versus "natureceuticals" in health care and medicine is based on effectiveness and availability, taking Vimang as an example of a natural product with supported scientific evidence to be used as antioxidant, analgesic, anti-inflammatory and immunomodulator.

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Year: 2007 PMID： 17314051 DOI： 10.1016/j.phrs.2007.01.004

Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658

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Cited

5 in total

1. Effects of a Mangifera indica L. stem bark extract and mangiferin on radiation-induced DNA damage in human lymphocytes and lymphoblastoid cells.

Authors: I Rodeiro; R Delgado; G Garrido
Journal: Cell Prolif Date: 2013-11-22 Impact factor: 6.831

5. Integrated Metabolome and Transcriptome Analysis of Fruit Flavor and Carotenoids Biosynthesis Differences Between Mature-Green and Tree-Ripe of cv. "Golden Phoenix" Mangoes (Mangifera indica L.).

Authors: Lei Peng; Wenke Gao; Miaoyu Song; Minghai Li; Dinan He; Ziran Wang
Journal: Front Plant Sci Date: 2022-02-24 Impact factor: 5.753

5 in total

The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract.

1. Effects of a Mangifera indica L. stem bark extract and mangiferin on radiation-induced DNA damage in human lymphocytes and lymphoblastoid cells.

2. Mangiferin prevents guinea pig tracheal contraction via activation of the nitric oxide-cyclic GMP pathway.

3. Mutagenic and antimutagenic effects of Heterotheca inuloides.

Review 4. A Mangifera indica L. extract could be used to treat neuropathic pain and implication of mangiferin.

5. Integrated Metabolome and Transcriptome Analysis of Fruit Flavor and Carotenoids Biosynthesis Differences Between Mature-Green and Tree-Ripe of cv. "Golden Phoenix" Mangoes (Mangifera indica L.).