OBJECTIVE: Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. METHODS:Red cell transketolase activation coefficients (alpha) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment. RESULTS: Twelve per cent of patients had biochemical evidence of severe deficiency (alpha values >1.31) at presentation, declining to 3% 42 days later. CONCLUSION: Thiamin deficiency was common in Lao patients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation.
RCT Entities:
OBJECTIVE:Thiamindeficiency complicates severe Plasmodium falciparummalaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamindeficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. METHODS: Red cell transketolase activation coefficients (alpha) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment. RESULTS: Twelve per cent of patients had biochemical evidence of severe deficiency (alpha values >1.31) at presentation, declining to 3% 42 days later. CONCLUSION:Thiamindeficiency was common in Laopatients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation.
Authors: Douangdao Soukaloun; Sengchanh Kounnavong; Bounthom Pengdy; Boungnong Boupha; Somchai Durondej; Karen Olness; Paul N Newton; Nicholas J White Journal: Ann Trop Paediatr Date: 2003-09
Authors: S Krishna; A M Taylor; W Supanaranond; S Pukrittayakamee; F ter Kuile; K M Tawfiq; P A Holloway; N J White Journal: Lancet Date: 1999-02-13 Impact factor: 79.321
Authors: Sysavanh Phommachanh; Dirk R Essink; Pamela E Wright; Jacqueline E W Broerse; Mayfong Mayxay Journal: PLoS One Date: 2021-03-29 Impact factor: 3.240