Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling.

Literature DB >> 17313179

The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling.

Abstract

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in cancer. Three new crystal structures of PP2A show how it interacts with inhibitory toxins and with one of its regulatory subunits. The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17313179 DOI： 10.1021/cb700021z

Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100

Keyword Cloud
Cited

28 in total

1. Identification of PP2A complexes and pathways involved in cell transformation.

Authors: Anna A Sablina; Melissa Hector; Nathalie Colpaert; William C Hahn
Journal: Cancer Res Date: 2010-12-15 Impact factor: 12.701

2. PP2A regulates the pro-apoptotic activity of FOXO1.

Authors: Ling Yan; Viviana A Lavin; Leta R Moser; Qinghua Cui; Cindy Kanies; Elizabeth Yang
Journal: J Biol Chem Date: 2008-01-21 Impact factor: 5.157

3. PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.

Authors: Vivian R Ruvolo; Svitlana M Kurinna; Kul B Karanjeet; Todd F Schuster; Alberto M Martelli; James A McCubrey; Peter P Ruvolo
Journal: J Biol Chem Date: 2008-10-28 Impact factor: 5.157

4. Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts.

Authors: Satoru Mochida; Satoshi Ikeo; Julian Gannon; Tim Hunt
Journal: EMBO J Date: 2009-08-20 Impact factor: 11.598

5. Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.

Authors: Gernot Walter; Ralf Ruediger
Journal: Cell Cycle Date: 2012-02-01 Impact factor: 4.534

6. Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function.

Authors: Yanrong Zhang; Xiaoliang Jiang; Chuan Qin; Santiago Cuevas; Pedro A Jose; Ines Armando
Journal: Am J Physiol Renal Physiol Date: 2015-08-19

Review 7. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases.

Authors: A Ishida; N Sueyoshi; Y Shigeri; I Kameshita
Journal: Br J Pharmacol Date: 2008-05-05 Impact factor: 8.739