Literature DB >> 17312960

Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids.

Rebecca J M Goss1, Simon E Lanceron, Nicola J Wise, Steven J Moss.   

Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

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Year:  2006        PMID： 17312960     DOI： 10.1039/b614519c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

Review 1.  Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.

Authors:  Shiva Krishna Reddy Guduru; Prabhat Arya
Journal:  Medchemcomm       Date:  2017-11-22       Impact factor: 3.597

2.  Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase.

Authors:  Brian J C Law; Anna-Winona Struck; Matthew R Bennett; Barrie Wilkinson; Jason Micklefield
Journal:  Chem Sci       Date:  2015-03-02       Impact factor: 9.825
  2 in total

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