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Literature DB >> 17311394

Polymer-supported (2,6-dichloro- 4-alkoxyphenyl)(2,4-dichlorophenyl)methanol: a new linker for solid-phase organic synthesis.

Michio Kurosu¹, Kallolmay Biswas, Dean C Crick.

Abstract

An acid and base stable hydroxytetrachlorodiphenylmethyl (HTPM) linker is developed for polymer-supported organic synthesis. The linkers reported here are utilized for loading carboxylic acids, amines, alcohols, and phenols, and are stable to Brønsted and Lewis acids, Brønsted bases, and a wide variety of nucleophiles. However, the HTPM linkers can conveniently be cleaved by the solvolytic displacement reactions with 20% TFA. [structure: see text]

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17311394 PMCID： PMC2577291 DOI： 10.1021/ol070150f

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

12 in total

Review 1. Target-oriented and diversity-oriented organic synthesis in drug discovery.

Authors: S L Schreiber
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2. Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry.

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3. Specificity of peptides; new aspects of the specificity of peptides with vitamin and hormone action are described.

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5. Solid-phase synthesis in lead optimization and drug discovery.

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Review 6. MraY Inhibitors as Novel Antibacterial Agents.

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7. Solid phase synthesis of protected peptides via photolytic cleavage of the alpha-methylphenacyl ester anchoring linkage.

Authors: S S Wang
Journal: J Org Chem Date: 1976-10-01 Impact factor: 4.354

Review 8. Automated synthesis of peptides.

Authors: R B Merrifield
Journal: Science Date: 1965-10-08 Impact factor: 47.728

9. Quality control in combinatorial chemistry: determinations of amounts and comparison of the "purity" of LC-MS-purified samples by NMR, LC-UV and CLND.

Authors: Elodie Letot; Guido Koch; Rocco Falchetto; Günter Bovermann; Lukas Oberer; Hans-Jörg Roth
Journal: J Comb Chem Date: 2005 May-Jun

10. Novel solid-phase synthesis of 1,2-dialkoxyindoles.

Authors: Zemin Wu; Nicholas J Ede
Journal: Org Lett Date: 2003-08-07 Impact factor: 6.005

7 in total

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Journal: Chemistry Date: 2013-09-06 Impact factor: 5.236

2. A reliable Pd-mediated hydrogenolytic deprotection of BOM group of uridine ureido nitrogen.

Authors: Bilal A Aleiwi; Michio Kurosu
Journal: Tetrahedron Lett Date: 2012-05-12 Impact factor: 2.415

3. A new protecting group and linker for uridine ureido nitrogen.

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Journal: Tetrahedron Date: 2012-04-09 Impact factor: 2.457

4. Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas.

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