| Literature DB >> 17309782 |
M Hajdu1, A Sebestyén, G Barna, L Reiniger, J Jánosi, L Sréter, J Várkonyi, J Demeter, L Kopper.
Abstract
Dysregulation of the Notch-pathway has been implicated in the pathogenesis of chronic lymphocytic leukaemia (B-CLL). We characterized the mRNA expression of Notch pathway elements in circulating normal B- and B-CLL cells, and compared expression profiles with clinical and prognostic data. Similar expression profiles were found in normal B-cells and B-CLL cells, however, most B-CLL samples showed lower Hairy/Enhancer of Split-1 expression than normal B-cells, which suggests that the pathway is not over-activated in B-CLL. The expression of Notch-pathway genes did not correlate with other prognostic factors of B-CLL. The importance of Notch-signalling in CLL cells in lymphatic tissue microenvironments remains to be determined.Entities:
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Year: 2007 PMID： 17309782 DOI： 10.1111/j.1365-3083.2006.01897.x
Source DB: PubMed Journal: Scand J Immunol ISSN： 0300-9475 Impact factor: 3.487