Literature DB >> 17309298

Bioactive metabolites from the Caribbean sponge Aka coralliphagum.

Achim Grube1, Michael Assmann, Ellen Lichte, Florenz Sasse, Joseph R Pawlik, Matthias Köck.   

Abstract

The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures were elucidated by NMR and MS experiments. The compounds were tested in a DPPH assay, in antimicrobial assays against bacteria, yeasts, and fungi, and in antiproliferation assays using cultures of mouse fibroblasts. The biological activity was linked to the presence of the ortho-hydroquinone moiety.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17309298     DOI： 10.1021/np0603018

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Siphonodictyal B1 from a marine sponge increases intracellular calcium levels comparable to the Ca2+-ATPase (SERCA) inhibitor thapsigargin.

Authors:  Ulf Bickmeyer; Achim Grube; Karl-Walter Klings; Joseph R Pawlik; Matthias Köck
Journal:  Mar Biotechnol (NY)       Date:  2009-07-16       Impact factor: 3.619

Review 2.  Cytotoxic terpene quinones from marine sponges.

Authors:  Marina Gordaliza
Journal:  Mar Drugs       Date:  2010-11-24       Impact factor: 5.118

Review 3.  Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Nobuhiro Fusetani
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2010-09-15       Impact factor: 3.228

Review 4.  Meroterpenes from marine invertebrates: structures, occurrence, and ecological implications.

Authors:  Marialuisa Menna; Concetta Imperatore; Filomena D'Aniello; Anna Aiello
Journal:  Mar Drugs       Date:  2013-05-17       Impact factor: 5.118

5.  A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds.

Authors:  Sony Pandey; Ayinampudi Sree; Dipti Priya Sethi; Chityal Ganesh Kumar; Sudha Kakollu; Lipsa Chowdhury; Soumya Suchismita Dash
Journal:  Microb Cell Fact       Date:  2014-02-15       Impact factor: 5.328

6.  New sesquiterpene hydroquinones from the Caribbean sponge Aka coralliphagum.

Authors:  Qun Göthel; Matthias Köck
Journal:  Beilstein J Org Chem       Date:  2014-03-06       Impact factor: 2.883

7.  The marine sponge Agelas citrina as a source of the new pyrrole-imidazole alkaloids citrinamines A-D and N-methylagelongine.

Authors:  Christine Cychon; Ellen Lichte; Matthias Köck
Journal:  Beilstein J Org Chem       Date:  2015-10-29       Impact factor: 2.883

8.  Bioinspired synthesis of pentacyclic onocerane triterpenoids.

Authors:  Florian Bartels; Young J Hong; Daijiro Ueda; Manuela Weber; Tsutomu Sato; Dean J Tantillo; Mathias Christmann
Journal:  Chem Sci       Date:  2017-10-16       Impact factor: 9.825
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.