Literature DB >> 1730927

Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue.

T A Barrett1, M L Delvy, D M Kennedy, L Lefrancois, L A Matis, A L Dent, S M Hedrick, J A Bluestone.   

Abstract

The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/delta cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-gamma/delta cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.

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Year:  1992        PMID： 1730927      PMCID： PMC2119083          DOI： 10.1084/jem.175.1.65

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  29 in total

1.  Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen.

Authors:  H Pircher; K Bürki; R Lang; H Hengartner; R M Zinkernagel
Journal:  Nature       Date:  1989-11-30       Impact factor: 49.962

2.  Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors.

Authors:  W L Havran; J P Allison
Journal:  Nature       Date:  1988-09-29       Impact factor: 49.962

3.  Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

Authors:  T F Gajewski; F W Fitch
Journal:  J Immunol       Date:  1988-06-15       Impact factor: 5.422

4.  Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

Authors:  R T Kubo; W Born; J W Kappler; P Marrack; M Pigeon
Journal:  J Immunol       Date:  1989-04-15       Impact factor: 5.422

5.  Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

Authors:  K M Murphy; C T Weaver; M Elish; P M Allen; D Y Loh
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

6.  In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

Authors:  B L Rellahan; L A Jones; A M Kruisbeek; A M Fry; L A Matis
Journal:  J Exp Med       Date:  1990-10-01       Impact factor: 14.307

7.  The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

Authors:  J Bill; O Kanagawa; D L Woodland; E Palmer
Journal:  J Exp Med       Date:  1989-04-01       Impact factor: 14.307

8.  Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.

Authors:  J A Bluestone; R Q Cron; M Cotterman; B A Houlden; L A Matis
Journal:  J Exp Med       Date:  1988-11-01       Impact factor: 14.307

9.  Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy.

Authors:  L A Jones; L T Chin; G R Merriam; L M Nelson; A M Kruisbeck
Journal:  J Exp Med       Date:  1990-11-01       Impact factor: 14.307

10.  Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

Authors:  T Goodman; L Lefrancois
Journal:  J Exp Med       Date:  1989-11-01       Impact factor: 14.307
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  16 in total

1.  Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestine.

Authors:  T Lin; H Yoshida; G Matsuzaki; S R Guehler; K Nomoto; T A Barrett; D R Green
Journal:  J Clin Invest       Date:  1999-11       Impact factor: 14.808

Review 2.  TCR gamma delta cells: mysterious cells of the immune system.

Authors:  R Sciammas; Y Tatsumi; A I Sperling; K Arunan; J A Bluestone
Journal:  Immunol Res       Date:  1994       Impact factor: 2.829

3.  Monocytes control gamma/delta T-cell responses by a secreted product.

Authors:  A J Okragly; M Hanby-Flarida; C L Baldwin
Journal:  Immunology       Date:  1995-12       Impact factor: 7.397

4.  Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

Authors:  M Kawaguchi; M Nanno; Y Umesaki; S Matsumoto; Y Okada; Z Cai; T Shimamura; Y Matsuoka; M Ohwaki; H Ishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

5.  Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease.

Authors:  T Lin; T Brunner; B Tietz; J Madsen; E Bonfoco; M Reaves; M Huflejt; D R Green
Journal:  J Clin Invest       Date:  1998-02-01       Impact factor: 14.808

Review 6.  Experimental autoimmune uveitis: molecular mimicry and oral tolerance.

Authors:  V K Singh; K Nagaraju
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829

7.  Activation of T-cell receptor-gammadelta+ cells in the intestinal epithelia of KN6 transgenic mice.

Authors:  M Kawaguchi-Miyashita; S Shimada; Y Matsuoka; M Ohwaki; M Nanno
Journal:  Immunology       Date:  2000-09       Impact factor: 7.397

8.  Human V delta 2+ gamma delta T-cell tolerance to foreign antigens of Toxoplasma gondii.

Authors:  T Hara; S Ohashi; Y Yamashita; T Abe; H Hisaeda; K Himeno; R A Good; K Takeshita
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

9.  Analysis of gamma delta V region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry.

Authors:  A Bucht; K Söderström; S Esin; J Grunewald; S Hagelberg; I Magnusson; H Wigzell; A Grönberg; R Kiessling
Journal:  Clin Exp Immunol       Date:  1995-01       Impact factor: 4.330

10.  The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.

Authors:  D Qian; A I Sperling; D W Lancki; Y Tatsumi; T A Barrett; J A Bluestone; F W Fitch
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205
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