Literature DB >> 17308904

Phimosis and topical steroids: new clinical findings.

Nicola Zampieri1, Michele Corroppolo, Veronica Zuin, Sanzio Bianchi, Francesco Saverio Camoglio.   

Abstract

Phimosis has been defined as unretractable foreskin without adherences and/or a circular band of tight prepuce preventing full retraction. The aim of this study is to evaluate the efficacy (response rate) of topical steroids for the treatment of tight phimosis at different age stages. After using the same medication with different dosage schemes, a retrospective analysis was carried out to assess the efficacy of topical steroids in the treatment of tight phimosis. Patients were divided into three groups: group A (betamethasone scheme A), group B (betamethasone scheme B) and group C (control group). Remission of phimosis, with a complete exposure and without a narrowing behind the glans, was considered a complete response to treatment. The outcomes were then related to dosage scheme and patient's age. The dosage for group A was more effective than the dosage for groups B and C (control group). Phimosis resolved in 90% (group A), 72% (group B) and 56% (group C) of cases. A successful treatment was closely related to the age of patients at the beginning of steroid application. The results showed that treatment with topical steroids, which in general gives good results, proved to be much more successful in patients aged between 4 and 8 years, suggesting the efficacy of an early beginning of the treatment.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17308904     DOI: 10.1007/s00383-007-1878-x

Source DB:  PubMed          Journal:  Pediatr Surg Int        ISSN: 0179-0358            Impact factor:   1.827


  25 in total

1.  [Treatment of phimosis with locally applied 0.05% clobetasol propionate. Prospective study with 108 children].

Authors:  Ali Iken; Sami Ben Mouelli; Eric Fontaine; Vincent Quenneville; Laurent Thomas; Daniel Beurton
Journal:  Prog Urol       Date:  2002-12       Impact factor: 0.915

2.  Differential modulation of glucocorticoid action by FK506 in A549 cells.

Authors:  Jamie D Croxtall; Mark Paul-Clark; Peter Th W Van Hal
Journal:  Biochem J       Date:  2003-11-15       Impact factor: 3.857

3.  The fate of the foreskin, a study of circumcision.

Authors:  D GAIRDNER
Journal:  Br Med J       Date:  1949-12-24

Review 4.  Medical management of phimosis in children: our experience with topical steroids.

Authors:  M A Monsour; H H Rabinovitch; G E Dean
Journal:  J Urol       Date:  1999-09       Impact factor: 7.450

5.  A nonsurgical approach to the treatment of phimosis: local nonsteroidal anti-inflammatory ointment application.

Authors:  M K Atilla; R Dündaröz; O Odabaş; H Oztürk; R Akin; E Gökçay
Journal:  J Urol       Date:  1997-07       Impact factor: 7.450

Review 6.  New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use.

Authors:  Benedetta Brazzini; Nicola Pimpinelli
Journal:  Am J Clin Dermatol       Date:  2002       Impact factor: 7.403

7.  Glucocorticoid resistance caused by reduced expression of the glucocorticoid receptor in cells from human vascular lesions.

Authors:  P J Bray; B Du; V M Mejia; S C Hao; E Deutsch; C Fu; R C Wilson; H Hanauske-Abel; T A McCaffrey
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-05       Impact factor: 8.311

8.  Treatment of phimosis with topical steroids in 194 children.

Authors:  James E Ashfield; Kyle R Nickel; D Robert Siemens; Andrew E MacNeily; J Curtis Nickel
Journal:  J Urol       Date:  2003-03       Impact factor: 7.450

9.  Dexamethasone modulates the metabolism of type IV collagen and fibronectin in human basement-membrane-forming fibrosarcoma (HT-1080) cells.

Authors:  A Oikarinen; T Salo; L Ala-Kokko; K Tryggvason
Journal:  Biochem J       Date:  1987-07-01       Impact factor: 3.857

10.  Topical steroid therapy as an alternative to circumcision for phimosis in boys younger than 3 years.

Authors:  James M Elmore; Linda A Baker; Warren T Snodgrass
Journal:  J Urol       Date:  2002-10       Impact factor: 7.450

View more
  7 in total

1.  [Phimosis].

Authors:  I Rübben; H Rübben
Journal:  Urologe A       Date:  2012-07       Impact factor: 0.639

2.  [Nonretractable foreskin in boys without complaints : An indication for circumcision?]

Authors:  K Eckert; N Janssen; M Franz; P Liedgens
Journal:  Urologe A       Date:  2017-03       Impact factor: 0.639

Review 3.  Is steroids therapy effective in treating phimosis? A meta-analysis.

Authors:  Jiaming Liu; Jin Yang; Yuntian Chen; Sihang Cheng; Chao Xia; Tuo Deng
Journal:  Int Urol Nephrol       Date:  2016-01-02       Impact factor: 2.370

4.  Effect of topical steroid (0.05% clobetasol propionate) treatment in children with severe phimosis.

Authors:  Chan Ho Lee; Sang Don Lee
Journal:  Korean J Urol       Date:  2013-09-10

5.  Ufasomes Mediated Cutaneous Delivery of Dexamethasone: Formulation and Evaluation of Anti-Inflammatory Activity by Carrageenin-Induced Rat Paw Edema Model.

Authors:  Rajkamal Mittal; Arvind Sharma; Sandeep Arora
Journal:  J Pharm (Cairo)       Date:  2012-11-25

6.  Evaluation of topical corticosteroids in children with phimosis through morphological and immunohistochemical analyses of the foreskin.

Authors:  Luis Gustavo Sabino Borges; Maria Flávia Meirelles; Natália Bernardes; Felipe Lopes de Castro; Fernanda Rodrigues Helmo; Laura Penna Rocha; Vicente de Paula Antunes Teixeira; Rosana Rosa Miranda Correa
Journal:  Afr J Paediatr Surg       Date:  2019 Jan-Mar

7.  Efficacy of topical steroid treatment in children with severe phimosis in China: A long-term single centre prospective study.

Authors:  Guanglun Zhou; Man Jiang; Zhilin Yang; Wanhua Xu; Shoulin Li
Journal:  J Paediatr Child Health       Date:  2021-07-02       Impact factor: 1.929

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.