PURPOSE: Lymph node metastasis from oral squamous cell carcinoma (SCC) correlates with a poor prognosis. Therefore, accurate assessment of lymph node status is crucial in treatment planning. Furthermore, prediction of delayed neck metastasis (DNM), especially in early stage tumors with a clinically negative (N0) neck, will determine the need for neck dissection or irradiation. In this study, we assess various clinical, histopathological and lymphangiogenic parameters in early stage oral SCC and their association with DNM. MATERIALS AND METHODS: Clinical, histological, and immunohistochemical analyses were undertaken for 29 patients with T1N0M0 or T2N0M0 oral SCC affecting the tongue or floor of mouth and correlated with the development of DNM. RESULTS: Tumor thickness, nuclear pleomorphism, pattern of invasion, and immunohistochemical expression of the lymphangiogenesis-associated molecules VEGFR-3 and VEGF-C were associated with DNM. CONCLUSIONS: Analysis of these parameters may help to identify patients who would benefit from a neck dissection or irradiation by predicting the likelihood of lymph node metastasis.
PURPOSE: Lymph node metastasis from oral squamous cell carcinoma (SCC) correlates with a poor prognosis. Therefore, accurate assessment of lymph node status is crucial in treatment planning. Furthermore, prediction of delayed neck metastasis (DNM), especially in early stage tumors with a clinically negative (N0) neck, will determine the need for neck dissection or irradiation. In this study, we assess various clinical, histopathological and lymphangiogenic parameters in early stage oral SCC and their association with DNM. MATERIALS AND METHODS: Clinical, histological, and immunohistochemical analyses were undertaken for 29 patients with T1N0M0 or T2N0M0 oral SCC affecting the tongue or floor of mouth and correlated with the development of DNM. RESULTS: Tumor thickness, nuclear pleomorphism, pattern of invasion, and immunohistochemical expression of the lymphangiogenesis-associated molecules VEGFR-3 and VEGF-C were associated with DNM. CONCLUSIONS: Analysis of these parameters may help to identify patients who would benefit from a neck dissection or irradiation by predicting the likelihood of lymph node metastasis.
Authors: Oleksandr Ekshyyan; Alok R Khandelwal; Xiaohua Rong; Tara Moore-Medlin; Xiaohui Ma; Jonathan Steven Alexander; Cherie-Ann O Nathan Journal: Am J Transl Res Date: 2016-11-15 Impact factor: 4.060
Authors: Yufeng Li; Shuting Bai; William Carroll; Dan Dayan; Joseph C Dort; Keith Heller; George Jour; Harold Lau; Carla Penner; Michael Prystowsky; Eben Rosenthal; Nicolas F Schlecht; Richard V Smith; Mark Urken; Marilena Vered; Beverly Wang; Bruce Wenig; Abdissa Negassa; Margaret Brandwein-Gensler Journal: Head Neck Pathol Date: 2012-12-19
Authors: Salvador Nares; Niki M Moutsopoulos; Nikola Angelov; Zoila G Rangel; Peter J Munson; Neha Sinha; Sharon M Wahl Journal: Am J Pathol Date: 2009-03-05 Impact factor: 4.307