| Literature DB >> 17307144 |
Kohei Kakishima1, Akiko Shiratsuchi, Azuma Taoka, Yoshinobu Nakanishi, Yoshihiro Fukumori.
Abstract
Nitric oxide (NO) plays a crucial role in the antimicrobial activity of host defense systems. We investigated the function of Pseudomonas aeruginosa NO reductase as a detoxifying enzyme in phagocytes. We found that the growth of the NO reductase-deficient mutant of P. aeruginosa under a microaerobic condition was inhibited by the exogenous NO. Furthermore, the intracellular survival assay within the NO-producing RAW 264.7 macrophages revealed that the wild-type strain survived longer than the NO reductase-deficient mutant. These results suggest that the P. aeruginosa NO reductase may contribute to the intracellular survival by acting as a counter component against the host's defense systems.Entities:
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Year: 2007 PMID： 17307144 DOI： 10.1016/j.bbrc.2007.02.017
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575