| Literature DB >> 17306980 |
Ales Imramovský1, Slovenko Polanc, Jarmila Vinsová, Marijan Kocevar, Josef Jampílek, Zuzana Recková, Jarmila Kaustová.
Abstract
The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-aminosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed.Entities:
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Year: 2007 PMID： 17306980 DOI： 10.1016/j.bmc.2007.01.051
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641