| Literature DB >> 17306896 |
Gary L Johnson1, Kazuhiro Nakamura.
Abstract
c-Jun N-terminal kinases (JNKs), also referred to as stress-activated kinases (SAPKs), were initially characterized by their activation in response to cell stress such as UV irradiation. JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair. Dysregulated JNK signaling is now believed to contribute to many diseases involving neurodegeneration, chronic inflammation, birth defects, cancer and ischemia/reperfusion injury. In this review, we present our current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease.Entities:
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Year: 2007 PMID： 17306896 PMCID： PMC1995559 DOI： 10.1016/j.bbamcr.2006.12.009
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002