OBJECTIVE: This study was undertaken to assess the effect of maternal periodontal disease on preterm delivery and/or birth of low-weight infants. STUDY DESIGN: We conducted a meta-analytic review of 5 medical databases (MEDLINE, EMBASE, LILACS, BIOSIS and PASCAL) for human observational studies linking preterm delivery and/or birth of low-weight infants to maternal periodontal disease. The MOOSE guidelines for meta-analysis of observational studies were followed. RESULTS: The literature search revealed 17 articles that met the inclusion criteria. Seven thousand one hundred fifty-one women participated in the studies, 1056 of whom delivered a preterm and/or low birthweight infant. The overall odds ratio was 2.83 (95% CI: 1.95-4.10, P < .0001). This pooled value needed to be interpreted cautiously because there appeared to be a clear trend for the better quality studies to be of lower association strength. CONCLUSION: These findings indicate a likely association, but it needs to be confirmed by large, well-designed, multicenter trials.
OBJECTIVE: This study was undertaken to assess the effect of maternal periodontal disease on preterm delivery and/or birth of low-weight infants. STUDY DESIGN: We conducted a meta-analytic review of 5 medical databases (MEDLINE, EMBASE, LILACS, BIOSIS and PASCAL) for human observational studies linking preterm delivery and/or birth of low-weight infants to maternal periodontal disease. The MOOSE guidelines for meta-analysis of observational studies were followed. RESULTS: The literature search revealed 17 articles that met the inclusion criteria. Seven thousand one hundred fifty-one women participated in the studies, 1056 of whom delivered a preterm and/or low birthweight infant. The overall odds ratio was 2.83 (95% CI: 1.95-4.10, P < .0001). This pooled value needed to be interpreted cautiously because there appeared to be a clear trend for the better quality studies to be of lower association strength. CONCLUSION: These findings indicate a likely association, but it needs to be confirmed by large, well-designed, multicenter trials.
Authors: David A Albert; Angela Ward; Pamela Allweiss; Dana T Graves; William C Knowler; Carol Kunzel; Rudolph L Leibel; Karen F Novak; Thomas W Oates; Panos N Papapanou; Ann Marie Schmidt; George W Taylor; Ira B Lamster; Evanthia Lalla Journal: Ann N Y Acad Sci Date: 2012-03-12 Impact factor: 5.691
Authors: Kristen S Marchi; Susan A Fisher-Owens; Jane A Weintraub; Zhiwei Yu; Paula A Braveman Journal: Public Health Rep Date: 2010 Nov-Dec Impact factor: 2.792
Authors: David A Albert; Melissa D Begg; Howard F Andrews; Sharifa Z Williams; Angela Ward; Mary Lee Conicella; Virginia Rauh; Janet L Thomson; Panos N Papapanou Journal: Am J Public Health Date: 2010-11-18 Impact factor: 9.308
Authors: Harvey A Schenkein; Thomas E Koertge; Robert Sabatini; Carol N Brooks; John C Gunsolley Journal: J Periodontol Date: 2011-08-05 Impact factor: 6.993
Authors: N Mobeen; I Jehan; N Banday; J Moore; E M McClure; O Pasha; L L Wright; R L Goldenberg Journal: Am J Obstet Gynecol Date: 2008-05 Impact factor: 8.661