OBJECTIVE: Striatal dysfunction has been traditionally implicated in the pathophysiology of schizophrenia. The purpose of this study is to examine the relationship between caudate nucleus volumes and clinical and cognitive features of schizophrenic patients in an early phase of their illness. METHODS: Caudate nucleus volumes in previously untreated first episode patients with non-affective psychosis (N=76) and healthy comparison subjects (N=45) were measured. Caudate nucleus volume in the right and left hemispheres were automatically segmented and analyzed using BRAINS2. Analysis of covariance was used to control for intracranial volume. Severity of clinical symptoms was assessed using SAPS and SANS total scores. The relationship between cognitive dimensions, and caudate nucleus volume was evaluated. Finally, we examined the correlation between caudate volumes and the duration of untreated illness (DUI), duration of untreated psychosis (DUP) and duration of prodrome period (DPP). RESULTS: Right, left, and total caudate nucleus volumes did not differ significantly between patients and controls. Those patients with a longer DUP have smaller caudate nucleus. In addition, caudate nucleus volume was positively correlated with the severity of psychotic symptomatology. No significant associations were found between caudate nucleus volume and cognitive functioning. CONCLUSION: This group of first episode schizophrenia patients did not exhibit significant volumetric anomalies of the caudate nucleus. Despite this lack of volumetric abnormalities, a delay in receiving antipsychotic treatment and the severity of initial positive symptomatology were significantly associated with reduced caudate volume.
OBJECTIVE:Striatal dysfunction has been traditionally implicated in the pathophysiology of schizophrenia. The purpose of this study is to examine the relationship between caudate nucleus volumes and clinical and cognitive features of schizophrenicpatients in an early phase of their illness. METHODS: Caudate nucleus volumes in previously untreated first episode patients with non-affective psychosis (N=76) and healthy comparison subjects (N=45) were measured. Caudate nucleus volume in the right and left hemispheres were automatically segmented and analyzed using BRAINS2. Analysis of covariance was used to control for intracranial volume. Severity of clinical symptoms was assessed using SAPS and SANS total scores. The relationship between cognitive dimensions, and caudate nucleus volume was evaluated. Finally, we examined the correlation between caudate volumes and the duration of untreated illness (DUI), duration of untreated psychosis (DUP) and duration of prodrome period (DPP). RESULTS: Right, left, and total caudate nucleus volumes did not differ significantly between patients and controls. Those patients with a longer DUP have smaller caudate nucleus. In addition, caudate nucleus volume was positively correlated with the severity of psychotic symptomatology. No significant associations were found between caudate nucleus volume and cognitive functioning. CONCLUSION: This group of first episode schizophreniapatients did not exhibit significant volumetric anomalies of the caudate nucleus. Despite this lack of volumetric abnormalities, a delay in receiving antipsychotic treatment and the severity of initial positive symptomatology were significantly associated with reduced caudate volume.
Authors: Ulrich Ettinger; Anne Schmechtig; Timothea Toulopoulou; Charmaine Borg; Claire Orrells; Sheena Owens; Kazunori Matsumoto; Neeltje E van Haren; Mei-Hua Hall; Veena Kumari; Philip K McGuire; Robin M Murray; Marco Picchioni Journal: Schizophr Bull Date: 2010-06-10 Impact factor: 9.306
Authors: Bjørn H Ebdrup; Birte Glenthøj; Hans Rasmussen; Bodil Aggernaes; Annika R Langkilde; Olaf B Paulson; Henrik Lublin; Arnold Skimminge; William Baaré Journal: J Psychiatry Neurosci Date: 2010-03 Impact factor: 6.186
Authors: Kelly K Anderson; Aristotle Voineskos; Benoit H Mulsant; Tony P George; Kwame J Mckenzie Journal: Can J Psychiatry Date: 2014-10 Impact factor: 4.356
Authors: Ashwinee Manivannan; William Foran; Maria Jalbrzikowski; Vishnu P Murty; Gretchen L Haas; Goda Tarcijonas; Beatriz Luna; Deepak K Sarpal Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2019-01-30
Authors: Ian Ellison-Wright; David C Glahn; Angela R Laird; Sarah M Thelen; Ed Bullmore Journal: Am J Psychiatry Date: 2008-04-01 Impact factor: 18.112
Authors: Casey E Krueger; David L Dean; Howard J Rosen; Cathra Halabi; Michael Weiner; Bruce L Miller; Joel H Kramer Journal: Alzheimer Dis Assoc Disord Date: 2010 Jan-Mar Impact factor: 2.703