OBJECTIVES: The aim of the study was to analyse the prevalence of cervical lipomatosis (CL) in HIV-infected patients on highly active antiretroviral therapy (HAART) and the factors associated with its development. METHODS: This was a multicentre, observational, 1:1 case-control study. HIV-infected patients with CL (cases) and HIV-infected patients from the same cohort, controlled for age (+/-5 years), sex and body mass index (+/-2.5 kg/m(2)) (controls), were included in the study, and a multiple conditional logistic regression was performed to identify factors related to CL. RESULTS: CL was reported in 80 patients (1.8%) from a cohort of 4214 patients on HAART followed up in 10 Spanish hospitals. CL was associated with time of exposure to stavudine [for each 6-month increase, odds ratio (OR) 5.82, 95% confidence interval (CI) 5.70-5.94, P=0.0073] and lipoatrophy (OR 8.04, 95% CI 2.93-22.02, P=0.00001). CONCLUSIONS: Although lipodystrophy is very frequent among HIV-infected patients on HAART, CL is an uncommon type of fat redistribution in this population, and in our cohort it was related to time of exposure to stavudine and lipoatrophy.
OBJECTIVES: The aim of the study was to analyse the prevalence of cervical lipomatosis (CL) in HIV-infectedpatients on highly active antiretroviral therapy (HAART) and the factors associated with its development. METHODS: This was a multicentre, observational, 1:1 case-control study. HIV-infectedpatients with CL (cases) and HIV-infectedpatients from the same cohort, controlled for age (+/-5 years), sex and body mass index (+/-2.5 kg/m(2)) (controls), were included in the study, and a multiple conditional logistic regression was performed to identify factors related to CL. RESULTS: CL was reported in 80 patients (1.8%) from a cohort of 4214 patients on HAART followed up in 10 Spanish hospitals. CL was associated with time of exposure to stavudine [for each 6-month increase, odds ratio (OR) 5.82, 95% confidence interval (CI) 5.70-5.94, P=0.0073] and lipoatrophy (OR 8.04, 95% CI 2.93-22.02, P=0.00001). CONCLUSIONS: Although lipodystrophy is very frequent among HIV-infectedpatients on HAART, CL is an uncommon type of fat redistribution in this population, and in our cohort it was related to time of exposure to stavudine and lipoatrophy.
Authors: Sher L Hendrickson; Lawrence A Kingsley; Eduardo Ruiz-Pesini; Jason C Poole; Lisa P Jacobson; Frank J Palella; Jay H Bream; Douglas C Wallace; Stephen J O'Brien Journal: J Acquir Immune Defic Syndr Date: 2009-06-01 Impact factor: 3.731
Authors: Giancarlo Ceccarelli; Gabriella d'Ettorre; Francesco Marchetti; Cecilia Rizza; Claudio M Mastroianni; Bruno Carlesimo; Vincenzo Vullo Journal: J Med Case Rep Date: 2011-02-17