F Farshadpour1, G J Hordijk, R Koole, P J Slootweg. 1. Department of Otolaryngology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. F.Farshadpour@azu.nl
Abstract
OBJECTIVE: To recognize specific clinicopathological characteristics of non-smoking and non-drinking (NSND) head and neck squamous cell carcinoma (HNSCC) patients. This can increase our knowledge regarding a potentially different carcinogenesis in these patients. STUDY DESIGN/ METHODS: Retrospective analysis of data for 195 NSND patients with HNSCC and comparison with data for patients with HNSCC obtained from the Netherlands Cancer Registry. RESULTS: Compared with all HNSCC patients in the Netherlands, our NSND patients with HNSCC were typically female (n = 142; 73%vs 26%), old at disease presentation (mean 73 years vs 64 years), and had tumors mainly of the oral cavity (n = 130; 66%vs 25%). Most tumors were stage I (n = 67; 34%) and stage IVA (n = 59; 30%). The incidence of second primary tumors (SPTs) was high (n = 32; 16%), mainly occurring in the oral cavity (n = 26; 13%). DISCUSSION/ CONCLUSION: Our study confirms that NSND HNSCC patients have different clinicopathological characteristics from those of the overall HNSCC population; however, the frequency of SPTs is as high in NSND patients as in patients who smoke and drink alcohol. More research, and particularly molecular data are needed to obtain a better understanding of head and neck cancer in NSND patients.
OBJECTIVE: To recognize specific clinicopathological characteristics of non-smoking and non-drinking (NSND) head and neck squamous cell carcinoma (HNSCC) patients. This can increase our knowledge regarding a potentially different carcinogenesis in these patients. STUDY DESIGN/ METHODS: Retrospective analysis of data for 195 NSND patients with HNSCC and comparison with data for patients with HNSCC obtained from the Netherlands Cancer Registry. RESULTS: Compared with all HNSCC patients in the Netherlands, our NSND patients with HNSCC were typically female (n = 142; 73%vs 26%), old at disease presentation (mean 73 years vs 64 years), and had tumors mainly of the oral cavity (n = 130; 66%vs 25%). Most tumors were stage I (n = 67; 34%) and stage IVA (n = 59; 30%). The incidence of second primary tumors (SPTs) was high (n = 32; 16%), mainly occurring in the oral cavity (n = 26; 13%). DISCUSSION/ CONCLUSION: Our study confirms that NSND HNSCCpatients have different clinicopathological characteristics from those of the overall HNSCC population; however, the frequency of SPTs is as high in NSND patients as in patients who smoke and drink alcohol. More research, and particularly molecular data are needed to obtain a better understanding of head and neck cancer in NSND patients.
Authors: Shu-Chun Chuang; Mazda Jenab; Julia E Heck; Cristina Bosetti; Renato Talamini; Keitaro Matsuo; Xavier Castellsague; Silvia Franceschi; Rolando Herrero; Deborah M Winn; Carlo La Vecchia; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Luigino Dal Maso; Karl Kelsey; Michael D McClean; Thomas Vaughan; Philip Lazarus; Joshua Muscat; Heribert Ramroth; Chu Chen; Stephen M Schwartz; Jose Eluf-Neto; Richard B Hayes; Mark Purdue; Stefania Boccia; Gabriella Cadoni; David Zaridze; Sergio Koifman; Maria Paula Curado; Wolfgang Ahrens; Simone Benhamou; Elena Matos; Pagona Lagiou; Neonilla Szeszenia-Dabrowska; Andrew F Olshan; Leticia Fernandez; Ana Menezes; Antonio Agudo; Alexander W Daudt; Franco Merletti; Gary J Macfarlane; Kristina Kjaerheim; Dana Mates; Ivana Holcatova; Stimson Schantz; Guo-Pei Yu; Lorenzo Simonato; Hermann Brenner; Heiko Mueller; David I Conway; Peter Thomson; Eleonora Fabianova; Ariana Znaor; Peter Rudnai; Claire M Healy; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Cancer Causes Control Date: 2011-10-29 Impact factor: 2.506
Authors: F Farshadpour; S Konings; E J M Speel; G J Hordijk; R Koole; M van Blokland; P J Slootweg; J A Kummer Journal: Patholog Res Int Date: 2011-07-12