Literature DB >> 17305585

myo-Inositol monophosphatase: a challenging target for mood stabilising drugs.

D J Miller1, R K Allemann.   

Abstract

myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.

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Year:  2007        PMID: 17305585     DOI: 10.2174/138955707779802624

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN: 1389-5575            Impact factor:   3.862


  4 in total

1.  3-exo-Chloro-8-oxabicyclo-[3.2.1]oct-6-ene-2,4-diol chloro-form 0.33-solvate.

Authors:  Viktor A Tafeenko; Leonid A Aslanov; Marina V Proskurnina; Sergei E Sosonyuk; Dmitrii A Khlevin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-06-13

2.  Ebselen has lithium-like effects on central 5-HT2A receptor function.

Authors:  I Antoniadou; M Kouskou; T Arsiwala; N Singh; S R Vasudevan; T Fowler; E Cadirci; G C Churchill; T Sharp
Journal:  Br J Pharmacol       Date:  2018-05-22       Impact factor: 8.739

3.  Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.

Authors:  Alistair K Brown; Guoyu Meng; Hemza Ghadbane; David J Scott; Lynn G Dover; Jérôme Nigou; Gurdyal S Besra; Klaus Fütterer
Journal:  BMC Struct Biol       Date:  2007-08-28

4.  Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.

Authors:  Noelia Ferruz; Gary Tresadern; Antonio Pineda-Lucena; Gianni De Fabritiis
Journal:  Sci Rep       Date:  2016-07-21       Impact factor: 4.379

  4 in total

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