Literature DB >> 17305347

C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids.

Adeeb El-Dahshan1, Steffen Weik, Jörg Rademann.   

Abstract

C-Acylations of polymer-supported 2-phosphoranylidene acetates ("linker reagents") with protected amino acids yielded 2-acyl-2-phosphoranylidene acetates as flexible intermediates for the C-terminal variation of carboxylic acids: peptidyl-2,3-diketoesters, peptidyl vinyl ketones, peptidyl-2-ketoaldehydes, and 1,3-diamino-2-hydroxy-propanes were obtained as products. [reaction: see text]

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Year:  2007        PMID： 17305347     DOI： 10.1021/ol062754+

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

Authors:  Klaus Hellmuth; Stefanie Grosskopf; Ching Tung Lum; Martin Würtele; Nadine Röder; Jens Peter von Kries; Marta Rosario; Jörg Rademann; Walter Birchmeier
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-14       Impact factor: 11.205

2.  A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.

Authors:  Lei Ju; Jeffrey W Bode
Journal:  Org Biomol Chem       Date:  2009-04-02       Impact factor: 3.876

3.  Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.

Authors:  Marco Florian Schmidt; Albert Isidro-Llobet; Michael Lisurek; Adeeb El-Dahshan; Jinzhi Tan; Rolf Hilgenfeld; Jörg Rademann
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 4.  Dynamic template-assisted strategies in fragment-based drug discovery.

Authors:  Marco F Schmidt; Jörg Rademann
Journal:  Trends Biotechnol       Date:  2009-08-11       Impact factor: 19.536
  4 in total

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