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Literature DB >> 1730496

Identification of the protective 44-kilodalton recombinant antigen of Ehrlichia risticii.

B Shankarappa¹, S K Dutta, B Mattingly-Napier.

Abstract

Protective studies were conducted with mice by using recombinantly produced antigens, polyacrylamide gel electrophoresis-fractionated antigens, and a monoclonal antibody specific to the 28-kDa antigen of Ehrlichia risticii. Analysis of E. risticii-infected cell culture used as the challenge inoculum indicated an inverse relationship between the progression of cell culture infection and the infective capability of E. risticii for mice. A recombinant 44-kDa antigen was found to protect mice considerably against challenge infection, while the monoclonal antibody and fractionated antigens were not protective. A potentiation of protection was observed when the recombinant 44-kDa antigen was combined with the recombinant 70-kDa antigen and used for mouse immunization.

Entities: Chemical Disease Gene Species

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Year: 1992 PMID： 1730496 PMCID： PMC257673 DOI： 10.1128/iai.60.2.612-617.1992

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

27 in total

1. Immunity in scrub typhus: resistance to induced reinfection.

Authors: J E SMADEL; H L LEY; F H DIERCKS; R TRAUB
Journal: AMA Arch Pathol Date: 1950-12

2. Molecular cloning and sequence analysis of the Sta58 major antigen gene of Rickettsia tsutsugamushi: sequence homology and antigenic comparison of Sta58 to the 60-kilodalton family of stress proteins.

Authors: C K Stover; D P Marana; G A Dasch; E V Oaks
Journal: Infect Immun Date: 1990-05 Impact factor: 3.441

1. Molecular cloning, sequence analysis, and expression of the gene encoding the immunodominant 32-kilodalton protein of Cowdria ruminantium.

Authors: A H van Vliet; F Jongejan; M van Kleef; B A van der Zeijst
Journal: Infect Immun Date: 1994-04 Impact factor: 3.441

1 in total

Identification of the protective 44-kilodalton recombinant antigen of Ehrlichia risticii.

1. Immunity in scrub typhus: resistance to induced reinfection.

2. Molecular cloning and sequence analysis of the Sta58 major antigen gene of Rickettsia tsutsugamushi: sequence homology and antigenic comparison of Sta58 to the 60-kilodalton family of stress proteins.

3. Characterization of monoclonal antibodies protecting mice against Rickettsia rickettsii.

Review 4. Comparative biology of intracellular parasitism.

5. Enzyme-linked immunosorbent assay for Potomac horse fever disease.

6. Reduced immune responsiveness and lymphoid depletion in mice infected with Ehrlichia risticii.

7. Detection of serum antibodies against Ehrlichia risticii in Potomac horse fever by enzyme-linked immunosorbent assay.

8. Causative ehrlichial organisms in Potomac horse fever.

9. Experimental reproduction of Potomac horse fever in horses with a newly isolated Ehrlichia organism.

10. Molecular cloning and analysis of recombinant major antigens of Ehrlichia risticii.

1. Molecular cloning, sequence analysis, and expression of the gene encoding the immunodominant 32-kilodalton protein of Cowdria ruminantium.