| Literature DB >> 17303692 |
Judith A Coppinger1, Roisin O'Connor, Kieran Wynne, Michelle Flanagan, Matthew Sullivan, Patricia B Maguire, Desmond J Fitzgerald, Gerard Cagney.
Abstract
Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.Entities:
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Year: 2007 PMID: 17303692 DOI: 10.1182/blood-2006-07-038539
Source DB: PubMed Journal: Blood ISSN: 0006-4971 Impact factor: 22.113