| Literature DB >> 17303421 |
Shaoqing Chen1, Li Chen, Nam T Le, Chunlin Zhao, Achyutharao Sidduri, Jian Ping Lou, Christophe Michoud, Louis Portland, Nicole Jackson, Jin-Jun Liu, Fred Konzelmann, Feng Chi, Christian Tovar, Qing Xiang, Yingsi Chen, Yang Wen, Lyubomir T Vassilev.
Abstract
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK1 activity in vitro, and block cell cycle progression in human tumor cell lines, suggesting a potential use as antitumor agents.Entities:
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Year: 2007 PMID： 17303421 DOI： 10.1016/j.bmcl.2007.01.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823