| Literature DB >> 17303364 |
B G Pereira1, C D Vianna-Soares, A Righi, M V B Pinheiro, M Z S Flores, E M Bezerra, V N Freire, V Lemos, E W S Caetano, B S Cavada.
Abstract
Characterization of nucleoside and non-nucleoside human immunodeficiency virus (HIV) reverse transcriptase inhibitors conformers, NRTIs and NNRTIs, respectively, is fundamental for an improved treatment of infected individuals. Three conformers in lamivudine I powder are quickly identified in this work by assignment of some Raman peaks to their vibrational frequencies, as obtained by first principles quantum chemical calculations. The method is proposed as a practical procedure for non-destructive identification, analysis, and process monitoring of NRTIs and NNRTIs conformers.Entities:
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Year: 2007 PMID： 17303364 DOI： 10.1016/j.jpba.2007.01.014
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935