| Literature DB >> 17303253 |
Miles D Chapman1, Edward J Thompson, Paul M Candler, Russell C Dale, Andrew J Church, Gavin Giovannoni.
Abstract
Three paired serial samples of CSF and serum (from days 8, 13 and 22) were taken from a patient referred to the National Hospital for Neurology and Neurosurgery with what was duly confirmed as having herpes simplex encephalitis using PCR. The samples were investigated using affinity-mediated immunoblotting followed by incubation with sodium thiocyanate. Digitisation of the blots enabled further analysis. We showed that the clones of antigen-specific IgG, which were produced intrathecally, were of higher relative affinity than polyclonal antigen-specific IgG.Entities:
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Year: 2007 PMID： 17303253 DOI： 10.1016/j.jneuroim.2007.01.002
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478