Literature DB >> 17303213

New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether.

Tatiana V Abramova1, Marat F Kassakin, Alexander A Lomzov, Dmitrii V Pyshnyi, Vladimir N Silnikov.   

Abstract

We report on the design, synthesis and some of the properties of the new oligonucleotide analogues based on morpholine nucleoside (MorB) subunits joined by an oxalyl diamide tether instead of a phosphate group. The synthetic strategy and oligomer design are optimized to easily obtain target substances without using protective groups. The dimers HOMorU-Ox-NHMorU, HOMorU-Ox-NHMorA, and uracil containing the hexamer HOMorU-(Ox-NHMorU)5 were synthesized. The structures of all substances were confirmed by 1H, 13C, NMR, and mass spectroscopy. Base stacking interactions in dimers were revealed by CD-spectra data.

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Year:  2007        PMID： 17303213     DOI： 10.1016/j.bioorg.2006.12.003

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  4 in total

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3.  Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics.

Authors:  Tatyana V Abramova; Sergey S Belov; Yulia V Tarasenko; Vladimir N Silnikov
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4.  Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3.

Authors:  Yuliya V Sherstyuk; Nikita V Ivanisenko; Alexandra L Zakharenko; Maria V Sukhanova; Roman Y Peshkov; Ilia V Eltsov; Mikhail M Kutuzov; Tatjana A Kurgina; Ekaterina A Belousova; Vladimir A Ivanisenko; Olga I Lavrik; Vladimir N Silnikov; Tatyana V Abramova
Journal:  Int J Mol Sci       Date:  2019-12-27       Impact factor: 5.923
  4 in total

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