| Literature DB >> 1730161 |
J Schiffenbauer1, L Wegrzyn, B P Croker.
Abstract
The (NZB x NZW)F1 mouse develops a lupus-like disease including anti-double-stranded DNA antibodies and renal disease. It has been demonstrated that genes linked to the H-2 locus contributed by NZW correlate with development of this disease. We investigated whether mice with identical class II molecules but different background genes could contribute to autoimmunity when crossed with NZB. We report that two strains, PL/J and BIO.PL, when crossed to NZB, do not result in F1 with autoimmunity. Therefore, background genes present in NZW but not in PL/J or BIO.PL contribute to the development of disease.Entities:
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Year: 1992 PMID： 1730161 DOI： 10.1016/0090-1229(92)90076-z
Source DB: PubMed Journal: Clin Immunol Immunopathol ISSN： 0090-1229