Literature DB >> 17301571

HIV-1 natural viral suppressors: control of viral replication in the absence of therapy.

Mohammad M Sajadi1, Alonso Heredia, Nhut Le, Neil T Constantine, Robert R Redfield.   

Abstract

The objective of this study was to identify and define a cohort of HIV-1-infected individuals with the ability to suppress HIV-1 replication naturally (patients with undetectable viral loads for at least 2 years without antiretroviral drugs). Proviral DNA ranged from one to 74 copies/10(6) peripheral blood mononuclear cells, with the mean value lower by 1-2 logs than long-term non-progressors. This ability to control HIV-1 viral replication naturally has led us to refer to them as natural viral suppressors.

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Year:  2007        PMID： 17301571     DOI： 10.1097/QAD.0b013e328013d9eb

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  30 in total

1.  Comprehensive analysis of unique cases with extraordinary control over HIV replication.

Authors:  Daniel Mendoza; Sarah A Johnson; Bennett A Peterson; Ven Natarajan; Maria Salgado; Robin L Dewar; Peter D Burbelo; Nicole A Doria-Rose; Erin H Graf; Jamieson H Greenwald; Jessica N Hodge; William L Thompson; Nancy A Cogliano; Cheryl L Chairez; Catherine A Rehm; Sara Jones; Claire W Hallahan; Joseph A Kovacs; Irini Sereti; Omar Sued; Sheila A Peel; Robert J O'Connell; Una O'Doherty; Tae-Wook Chun; Mark Connors; Stephen A Migueles
Journal:  Blood       Date:  2012-04-05       Impact factor: 22.113

2.  Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.

Authors:  Mohammad Mohseni Sajadi; Amir Dashti; Zahra Rikhtegaran Tehrani; William D Tolbert; Michael S Seaman; Xin Ouyang; Neelakshi Gohain; Marzena Pazgier; Dongkyoon Kim; Guy Cavet; Jean Yared; Robert R Redfield; George K Lewis; Anthony L DeVico
Journal:  Cell       Date:  2018-05-03       Impact factor: 41.582

3.  Correlation between circulating HIV-1 RNA and broad HIV-1 neutralizing antibody activity.

Authors:  Mohammad M Sajadi; Yongjun Guan; Anthony L DeVico; Michael S Seaman; Mian Hossain; George K Lewis; Robert R Redfield
Journal:  J Acquir Immune Defic Syndr       Date:  2011-05-01       Impact factor: 3.731

4.  Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infection.

Authors:  Yongjun Guan; Mohammad M Sajadi; Roberta Kamin-Lewis; Timothy R Fouts; Anthony Dimitrov; Zhixin Zhang; Robert R Redfield; Anthony L DeVico; Robert C Gallo; George K Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-18       Impact factor: 11.205

5.  IL28B genotype does not correlate with HIV control in African Americans.

Authors:  Mohammad M Sajadi; Nahzinine Shakeri; Rohit Talwani; Charles D Howell; Ruth Pakyz; Robert R Redfield; Afshin Parsa
Journal:  Clin Transl Sci       Date:  2011-08       Impact factor: 4.689

6.  Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells.

Authors:  David J Riedel; Mohammad M Sajadi; Cheryl L Armstrong; Jean-Saville Cummings; Cristiana Cairo; Robert R Redfield; C David Pauza
Journal:  AIDS       Date:  2009-09-24       Impact factor: 4.177

Review 7.  Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications.

Authors:  Haishan Li; Suchita Chaudhry; Suchita Chaudry; Bhawna Poonia; Yiming Shao; C David Pauza
Journal:  Cell Mol Immunol       Date:  2012-12-17       Impact factor: 11.530

8.  The γδ T-cell receptor repertoire is reconstituted in HIV patients after prolonged antiretroviral therapy.

Authors:  Suchita Chaudhry; Cristiana Cairo; Vanessa Venturi; C David Pauza
Journal:  AIDS       Date:  2013-06-19       Impact factor: 4.177

9.  Epidemiologic characteristics and natural history of HIV-1 natural viral suppressors.

Authors:  Mohammad M Sajadi; Neil T Constantine; Dean L Mann; Manhattan Charurat; Elham Dadzan; Peter Kadlecik; Robert R Redfield
Journal:  J Acquir Immune Defic Syndr       Date:  2009-04-01       Impact factor: 3.731

10.  HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.

Authors:  Benoît Vingert; Santiago Perez-Patrigeon; Patricia Jeannin; Olivier Lambotte; Faroudy Boufassa; Fabrice Lemaître; William W Kwok; Ioannis Theodorou; Jean-François Delfraissy; Jacques Thèze; Lisa A Chakrabarti
Journal:  PLoS Pathog       Date:  2010-02-26       Impact factor: 6.823
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