| Literature DB >> 1730145 |
L Zhang1, K Sannes, A J Shusterman, C Hansch.
Abstract
From a study of 239 aromatic and heteroaromatic compounds causing skin cancer in mice, a quantitative structure-activity relationship has been derived. Carcinogenicity depends heavily on the relative hydrophobicity of the chemicals as defined by octanol/water partition coefficients (log P). It is also correlated with the energy of the highest occupied molecular orbital and the presence of substituents on the L and K regions of the carcinogen. The results are discussed in terms of the bay region concept for carcinogenic activity.Entities:
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Year: 1992 PMID： 1730145 DOI： 10.1016/0009-2797(92)90032-g
Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192