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Literature DB >> 17300982

Copper and Alzheimer's disease.

Paul S Donnelly¹, Zhiguang Xiao, Anthony G Wedd.

Abstract

Copper is essential for some of the enzymes that have a role in brain metabolism. Sophisticated mechanisms balance copper import and export to ensure proper nutrient levels (homeostasis) while minimizing toxic effects. Several neurodegenerative diseases including Alzheimer's disease (AD) are characterized by modified copper homeostasis. This change seems to contribute either directly or indirectly to increased oxidative stress, an important factor in neuronal toxicity. When coupled to misfolded proteins, this modified copper homeostasis appears to be an important factor in the pathological progression of AD.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2007 PMID： 17300982 DOI： 10.1016/j.cbpa.2007.01.678

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

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Cited

37 in total

Review 1. Metals in the "omics" world: copper homeostasis and cytochrome c oxidase assembly in a new light.

Authors: Ivano Bertini; Gabriele Cavallaro
Journal: J Biol Inorg Chem Date: 2007-11-07 Impact factor: 3.358

2. Probing transient copper chaperone-Wilson disease protein interactions at the single-molecule level with nanovesicle trapping.

Authors: Jaime J Benítez; Aaron M Keller; Patrick Ochieng; Liliya A Yatsunyk; David L Huffman; Amy C Rosenzweig; Peng Chen
Journal: J Am Chem Soc Date: 2008-02-05 Impact factor: 15.419

3. Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes.

Authors: Richard A Himes; Ga Young Park; Gnana Sutha Siluvai; Ninian J Blackburn; Kenneth D Karlin
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

4. The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations.

Authors: Ariel R Levy; Meital Turgeman; Lada Gevorkyan-Aiapetov; Sharon Ruthstein
Journal: Protein Sci Date: 2017-05-31 Impact factor: 6.725

10. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors: Douglas B Kell
Journal: BMC Med Genomics Date: 2009-01-08 Impact factor: 3.063

Copper and Alzheimer's disease.

Review 1. Metals in the "omics" world: copper homeostasis and cytochrome c oxidase assembly in a new light.

2. Probing transient copper chaperone-Wilson disease protein interactions at the single-molecule level with nanovesicle trapping.

3. Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes.

4. The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations.

5. Role of the cellular prion protein in the neuron adaptation strategy to copper deficiency.

Review 6. Tackling metal regulation and transport at the single-molecule level.

Review 7. Fluorescent sensors for measuring metal ions in living systems.

8. Copper-triggered aggregation of ubiquitin.

9. Copper(II) binding to alpha-synuclein, the Parkinson's protein.

10. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.