Literature DB >> 17300931

Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.

Hao Chen1, Janet L Taylor, Suzanne R Abrams.   

Abstract

A library of potential antifungal triazole-modified beta-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.

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Year:  2007        PMID： 17300931     DOI： 10.1016/j.bmcl.2007.01.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR.

Authors:  Lili Ou; Shuang Han; Wenbo Ding; Ping Jia; Bo Yang; Jose L Medina-Franco; Marc A Giulianotti; Jian-Zhong Chen; Yongping Yu
Journal:  Mol Divers       Date:  2011-07-10       Impact factor: 2.943

2.  Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one analogues.

Authors:  Dongyan Yang; Chuan Wan; MengMeng He; Chuanliang Che; Yumei Xiao; Bin Fu; Zhaohai Qin
Journal:  Medchemcomm       Date:  2017-03-08       Impact factor: 3.597
  2 in total

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