BACKGROUND: This study sought to replicate previous findings of worsened performance on a translational spatial working memory task among antipsychotic-naïve first-episode schizophrenia patients after antipsychotic treatment and to extend these findings by examining whether changes in the allocation of covert attention contribute to this effect. METHODS: Fourteen antipsychotic-naïve schizophrenia patients performed an oculomotor delayed response task before and 6 weeks after antipsychotic treatment (risperidone n = 11; olanzapine n = 3). Fifteen matched healthy individuals were studied in parallel. RESULTS: Patients' pretreatment deficit in accurately remembering spatial locations was exacerbated by antipsychotic treatment, consistent with previous findings; however, this occurred only when covert attention was directed away from remembered locations during delay periods. CONCLUSIONS: Disruption in the allocation of covert attention might contribute to patients' decline in spatial working memory after antipsychotic treatment. Alterations in prefrontal dopaminergic systems or reduced thalamocortical drive might account for this apparent adverse cognitive effect of antipsychotic treatment.
BACKGROUND: This study sought to replicate previous findings of worsened performance on a translational spatial working memory task among antipsychotic-naïve first-episode schizophreniapatients after antipsychotic treatment and to extend these findings by examining whether changes in the allocation of covert attention contribute to this effect. METHODS: Fourteen antipsychotic-naïve schizophreniapatients performed an oculomotor delayed response task before and 6 weeks after antipsychotic treatment (risperidone n = 11; olanzapine n = 3). Fifteen matched healthy individuals were studied in parallel. RESULTS:Patients' pretreatment deficit in accurately remembering spatial locations was exacerbated by antipsychotic treatment, consistent with previous findings; however, this occurred only when covert attention was directed away from remembered locations during delay periods. CONCLUSIONS: Disruption in the allocation of covert attention might contribute to patients' decline in spatial working memory after antipsychotic treatment. Alterations in prefrontal dopaminergic systems or reduced thalamocortical drive might account for this apparent adverse cognitive effect of antipsychotic treatment.
Authors: S Kristian Hill; Alison Buchholz; Hayley Amsbaugh; James L Reilly; Leah H Rubin; James M Gold; Richard S E Keefe; Godfrey D Pearlson; Matcheri S Keshavan; Carol A Tamminga; John A Sweeney Journal: Schizophr Res Date: 2015-05-23 Impact factor: 4.939
Authors: Sarah K Keedy; Jeffrey R Bishop; Peter J Weiden; John A Sweeney; Cherise Rosen; Robert Marvin; James L Reilly Journal: Schizophr Res Date: 2014-08-08 Impact factor: 4.939
Authors: Jeffrey R Bishop; James L Reilly; Margret S H Harris; Shitalben R Patel; Rick Kittles; Judith A Badner; Konasale M Prasad; Vishwajit L Nimgaonkar; Matcheri S Keshavan; John A Sweeney Journal: Psychopharmacology (Berl) Date: 2014-08-07 Impact factor: 4.530
Authors: Gabriel Selva-Vera; Vicent Balanzá-Martínez; José Salazar-Fraile; José Sánchez-Moreno; Anabel Martinez-Aran; Patricia Correa; Eduard Vieta; Rafael Tabarés-Seisdedos Journal: BMC Psychiatry Date: 2010-06-15 Impact factor: 3.630