BACKGROUND:Flashlamp-pumped pulsed dye lasers (PDLs) have successfully treated keloidal and hypertrophic scars. OBJECTIVE: The objective was to investigate the effect of pulse width of a PDL in treating keloidal and hypertrophic scars. METHODS: On each of 19 patients, keloidal or hypertrophic median sternotomy scars were divided into two segments. Both segments on all patients were randomly treated with a 595-nm PDL at a fluence of 7 J/cm(2) and pulse widths of 0.45 and 40 ms to both segments, every 4 weeks for a total of three treatments. Scar volume, height, erythema, and pliability were measured at Weeks 0, 4, 8, and 24. RESULTS: The volume of segments treated with 0.45- and 40-ms pulses decreased significantly after two treatments. Segments treated with a 0.45-ms pulse width showed significantly greater improvement than those treated with 40-ms pulses after three treatments. Elasticity of 0.45-ms segments was significantly higher than those of 40-ms segments, following two treatments. Pulse width had no significant effect in improvement of scar erythema. CONCLUSIONS: A pulse width of 0.45 ms of PDL was more effective in decreasing scar size and improving scar pliability than that of 40 ms. A 595-nm PDL was safe and effective in treatment of hypertrophic scars and keloids in dark-skinned individuals. This study was supported in part by an educational grant from the Dermatological Society of Thailand.
RCT Entities:
BACKGROUND:Flashlamp-pumped pulsed dye lasers (PDLs) have successfully treated keloidal and hypertrophic scars. OBJECTIVE: The objective was to investigate the effect of pulse width of a PDL in treating keloidal and hypertrophic scars. METHODS: On each of 19 patients, keloidal or hypertrophic median sternotomy scars were divided into two segments. Both segments on all patients were randomly treated with a 595-nm PDL at a fluence of 7 J/cm(2) and pulse widths of 0.45 and 40 ms to both segments, every 4 weeks for a total of three treatments. Scar volume, height, erythema, and pliability were measured at Weeks 0, 4, 8, and 24. RESULTS: The volume of segments treated with 0.45- and 40-ms pulses decreased significantly after two treatments. Segments treated with a 0.45-ms pulse width showed significantly greater improvement than those treated with 40-ms pulses after three treatments. Elasticity of 0.45-ms segments was significantly higher than those of 40-ms segments, following two treatments. Pulse width had no significant effect in improvement of scar erythema. CONCLUSIONS: A pulse width of 0.45 ms of PDL was more effective in decreasing scar size and improving scar pliability than that of 40 ms. A 595-nm PDL was safe and effective in treatment of hypertrophic scars and keloids in dark-skinned individuals. This study was supported in part by an educational grant from the Dermatological Society of Thailand.
Authors: Rafael Leszczynski; Carolina Ap da Silva; Ana Carolina Pereira Nunes Pinto; Uliana Kuczynski; Edina Mk da Silva Journal: Cochrane Database Syst Rev Date: 2022-09-26
Authors: Gabriella Fabbrocini; M C Annunziata; V D'Arco; V De Vita; G Lodi; M C Mauriello; F Pastore; G Monfrecola Journal: Dermatol Res Pract Date: 2010-10-14
Authors: Steven Nisticò; Piero Campolmi; Silvia Moretti; Ester Del Duca; Nicola Bruscino; Rossana Conti; Andrea Bassi; Giovanni Cannarozzo Journal: Biomed Res Int Date: 2016-08-18 Impact factor: 3.411