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Literature DB >> 17299454

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.

Abstract

Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments. Avoiding danger and finding food, which are life-essential activities that are regulated by emotion, reward and energy balance, require vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis.

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Year: 2007 PMID： 17299454 DOI： 10.1038/nrn2092

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

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Cited

374 in total

1. Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women.

Authors: Gregory J Tranah; Terri Blackwell; Katie L Stone; Sonia Ancoli-Israel; Misti L Paudel; Kristine E Ensrud; Jane A Cauley; Susan Redline; Teresa A Hillier; Steven R Cummings; Kristine Yaffe
Journal: Ann Neurol Date: 2011-11 Impact factor: 10.422

2. Cognitive activation by central thalamic stimulation: the yerkes-dodson law revisited.

Authors: Robert G Mair; Kristen D Onos; Jacqueline R Hembrook
Journal: Dose Response Date: 2010-08-20 Impact factor: 2.658

3. Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.

Authors: Laura H Jacobson; S Renee Commerford; Sarah P Gerber; Yu Alice Chen; Beatriz Dardik; Frederique Chaperon; Chad Schwartzkopf; Van Nguyen-Tran; Thomas Hollenbeck; Peter McNamara; Xiaohui He; Hong Liu; H Martin Seidel; Anne-Liese Jaton; Jesper Gromada; Sandra Teixeira
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2011-09-25 Impact factor: 3.000

Review 4. Drug-induced sleep: theoretical and practical considerations.

Authors: Jeffrey M Ellenbogen; Edward F Pace-Schott
Journal: Pflugers Arch Date: 2011-09-28 Impact factor: 3.657

5. The injection of hypocretin-1 into the nucleus pontis oralis induces either active sleep or wakefulness depending on the behavioral state when it is administered.

Authors: Mingchu Xi; Michael H Chase
Journal: Sleep Date: 2010-09 Impact factor: 5.849

6. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.

Authors: Israt Z Shahid; Ahmed A Rahman; Paul M Pilowsky
Journal: Br J Pharmacol Date: 2012-04 Impact factor: 8.739

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.

1. Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women.

2. Cognitive activation by central thalamic stimulation: the yerkes-dodson law revisited.

3. Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.

Review 4. Drug-induced sleep: theoretical and practical considerations.

5. The injection of hypocretin-1 into the nucleus pontis oralis induces either active sleep or wakefulness depending on the behavioral state when it is administered.

6. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.

7. Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats.

8. Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle.

9. Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.

Review 10. Hypothalamic Dysfunction and Multiple Sclerosis: Implications for Fatigue and Weight Dysregulation.