| Literature DB >> 17298878 |
C H Lau1, C M Chan, Y W Chan, K M Lau, T W Lau, F C Lam, W T Law, C T Che, P C Leung, K P Fung, Y Y Ho, C B S Lau.
Abstract
Cortex Moutan (CM, root bark of Paeonia suffruticosa Andr.) is one of the common herbs found in anti-diabetic traditional Chinese medicine formulae. To study the potential anti-diabetic mechanisms of CM, four in vitro models (intestinal brush border membrane vesicles (BBMV), rat hepatoma cell line H4IIE, human skin fibroblasts cell line Hs68 and mouse adipocytes 3T3-L1) were used. CM showed significant in vitro anti-diabetic effects by inhibiting glucose uptake of BBMV and enhancing glucose uptake into Hs68 and 3T3-L1 cells. Using bioassay-guided fractionation, paeonol was confirmed to be one of the active constituents for inhibiting BBMV glucose uptake. With neonatal-streptozotocin diabetic rats, paeonol (200 and 400mg/kgbody wt.) was found to improve oral glucose tolerance in vivo. To the best of our knowledge, this is the first report on the anti-diabetic effect of paeonol.Entities:
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Year: 2007 PMID： 17298878 DOI： 10.1016/j.phymed.2007.01.007
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340