Erkan Ceylan1, Mehmet Gencer, Imran San. 1. Department of Chest Diseases, Harran University, Faculty of Medicine, Turkey. drerkanceylan@yahoo.com
Abstract
BACKGROUND AND OBJECTIVES: Upper airway pathologies often accompany asthma. Because this represents a single airway, the diagnosis, follow up and treatment of both upper and lower respiratory diseases is essential. Samter Syndrome (SS) is known to be associated with more severe asthma. The presence of nasal polyps (NPs) is also associated with asthma. However, the incidence of NPs in asthma and the effect of NPs on asthma severity are not well documented. METHODS: Three hundred and forty-two asthma patients were evaluated by endoscopic nasal examination, pulmonary function test, skin prick tests and paranasal sinus tomography. RESULTS: Three hundred and eleven patients with asthma without NP, 19 asthma patients with NP and 12 patients with SS were included. It was found that 54.3% of patients without NPs, 63.2% with NP and 66.7% with SS were at step 3 on the Global Initiative for Asthma scale of severity, and 1.9%, 15.8% and 33.3% were at step 4, respectively. CONCLUSIONS: The presence of NPs in asthma patients is associated with an increase in asthma severity. In patients with asthma, the possibility of NPs should be investigated and treatment planned accordingly.
BACKGROUND AND OBJECTIVES: Upper airway pathologies often accompany asthma. Because this represents a single airway, the diagnosis, follow up and treatment of both upper and lower respiratory diseases is essential. Samter Syndrome (SS) is known to be associated with more severe asthma. The presence of nasal polyps (NPs) is also associated with asthma. However, the incidence of NPs in asthma and the effect of NPs on asthma severity are not well documented. METHODS: Three hundred and forty-two asthmapatients were evaluated by endoscopic nasal examination, pulmonary function test, skin prick tests and paranasal sinus tomography. RESULTS: Three hundred and eleven patients with asthma without NP, 19 asthmapatients with NP and 12 patients with SS were included. It was found that 54.3% of patients without NPs, 63.2% with NP and 66.7% with SS were at step 3 on the Global Initiative for Asthma scale of severity, and 1.9%, 15.8% and 33.3% were at step 4, respectively. CONCLUSIONS: The presence of NPs in asthmapatients is associated with an increase in asthma severity. In patients with asthma, the possibility of NPs should be investigated and treatment planned accordingly.
Authors: Mark C Liu; Bradley Chipps; Xavier Munoz; Gilles Devouassoux; Miguel Bergna; Steven G Smith; Robert G Price; Dmitry V Galkin; Jay Azmi; Dalal Mouneimne; Frank C Albers; Kenneth R Chapman Journal: Respir Res Date: 2021-05-10
Authors: Jorge Maspero; Yochai Adir; Mona Al-Ahmad; Carlos A Celis-Preciado; Federico D Colodenco; Pedro Giavina-Bianchi; Hani Lababidi; Olivier Ledanois; Bassam Mahoub; Diahn-Warng Perng; Juan C Vazquez; Arzu Yorgancioglu Journal: ERJ Open Res Date: 2022-08-01