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Literature DB >> 1729693

Chromosomal context dependence of a eukaryotic recombinational hot spot.

Abstract

The single base-pair mutation M26 in the ade6 gene of the fission yeast Schizosaccharomyces pombe creates a hot spot for meiotic homologous recombination. When DNA fragments containing M26 and up to 3.0 kilobases of surrounding DNA were moved to the ura4 gene or to a multicopy plasmid, M26 had no detectable hot spot activity. Our results indicate that nucleotide sequences at least 1 kilobase away from M26 are required for M26 hot spot activity and suggest that, as for transcriptional promoters, a second site or proper chromatin structure is required for activation of this eukaryotic recombinational hot spot. We discuss the implications of these results for studies of other meiotic recombinational hot spots and for gene targeting.

Entities: Species

Mesh：

Year: 1992 PMID： 1729693 PMCID： PMC48209 DOI： 10.1073/pnas.89.1.227

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. The mechanism of the chi-cos interaction in RecA-RecBC-mediated recombination in phage lambda.

Authors: I Kobayashi; M M Stahl; F W Stahl
Journal: Cold Spring Harb Symp Quant Biol Date: 1984

2. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

Authors: P Russell; P Nurse
Journal: Cell Date: 1987-05-22 Impact factor: 41.582

Review 3. Nuclease hypersensitive sites in chromatin.

Authors: D S Gross; W T Garrard
Journal: Annu Rev Biochem Date: 1988 Impact factor: 23.643

4. Genetic and physical analysis of the M26 recombination hotspot of Schizosaccharomyces pombe.

Authors: A S Ponticelli; E P Sena; G R Smith
Journal: Genetics Date: 1988-07 Impact factor: 4.562

5. Chi-dependent DNA strand cleavage by RecBC enzyme.

Authors: A S Ponticelli; D W Schultz; A F Taylor; G R Smith
Journal: Cell Date: 1985-05 Impact factor: 41.582

6. RecBC enzyme nicking at Chi sites during DNA unwinding: location and orientation-dependence of the cutting.

Authors: A F Taylor; D W Schultz; A S Ponticelli; G R Smith
Journal: Cell Date: 1985-05 Impact factor: 41.582

Review 7. Genetic nomenclature and gene list of the fission yeast Schizosaccharomyces pombe.

Authors: J Kohli
Journal: Curr Genet Date: 1987 Impact factor: 3.886

8. Replicating plasmids in Schizosaccharomyces pombe: improvement of symmetric segregation by a new genetic element.

Authors: W D Heyer; M Sipiczki; J Kohli
Journal: Mol Cell Biol Date: 1986-01 Impact factor: 4.272

9. Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker.

Authors: C Grimm; J Kohli; J Murray; K Maundrell
Journal: Mol Gen Genet Date: 1988-12

10. Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation.

Authors: D Beach; M Piper; P Nurse
Journal: Mol Gen Genet Date: 1982

37 in total

1. The evolution of tandemly repetitive DNA: recombination rules.

Authors: R M Harding; A J Boyce; J B Clegg
Journal: Genetics Date: 1992-11 Impact factor: 4.562

2. High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae.

Authors: Xuan Zhu; Scott Keeney
Journal: Genetics Date: 2015-08-05 Impact factor: 4.562

10. Transcript identification in the optomotor-blind locus of Drosophila melanogaster by intragenic recombination mapping and PCR-aided sequence analysis of lethal point mutations.

Authors: B Poeck; J Balles; G O Pflugfelder
Journal: Mol Gen Genet Date: 1993-04

Chromosomal context dependence of a eukaryotic recombinational hot spot.

1. The mechanism of the chi-cos interaction in RecA-RecBC-mediated recombination in phage lambda.

2. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

Review 3. Nuclease hypersensitive sites in chromatin.

4. Genetic and physical analysis of the M26 recombination hotspot of Schizosaccharomyces pombe.

5. Chi-dependent DNA strand cleavage by RecBC enzyme.

6. RecBC enzyme nicking at Chi sites during DNA unwinding: location and orientation-dependence of the cutting.

Review 7. Genetic nomenclature and gene list of the fission yeast Schizosaccharomyces pombe.

8. Replicating plasmids in Schizosaccharomyces pombe: improvement of symmetric segregation by a new genetic element.

9. Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker.

10. Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation.

1. The evolution of tandemly repetitive DNA: recombination rules.

2. High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae.

3. Differential activation of M26-containing meiotic recombination hot spots in Schizosaccharomyces pombe.

4. Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe.

5. Important characteristics of sequence-specific recombination hotspots in Schizosaccharomyces pombe.

6. Pollen fertility restoration by nuclear gene Fr in CMS common bean: an Fr linkage map and the mode of Fr action.

7. The distance-dependence of the fission yeast ade6-M26 marker effect in two-factor crosses.

8. Relationship between transcription and initiation of meiotic recombination: toward chromatin accessibility.

9. Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome.

10. Transcript identification in the optomotor-blind locus of Drosophila melanogaster by intragenic recombination mapping and PCR-aided sequence analysis of lethal point mutations.