Literature DB >> 17296755

Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on Toll-like receptors 2 and 4.

Kathleen H Cox1, Itzhak Ofek, David L Hasty.   

Abstract

Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases of interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA plus Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

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Year:  2007        PMID： 17296755      PMCID： PMC1865771          DOI： 10.1128/IAI.01320-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide.

Authors:  F Y Jin; C Nathan; D Radzioch; A Ding
Journal:  Cell       Date:  1997-02-07       Impact factor: 41.582

2.  A murine macrophage cell line, immortalized by v-raf and v-myc oncogenes, exhibits normal macrophage functions.

Authors:  E Blasi; D Radzioch; S K Durum; L Varesio
Journal:  Eur J Immunol       Date:  1987-10       Impact factor: 5.532

3.  Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two.

Authors:  Mark J Paul-Clark; Shaun K McMaster; Elizabeth Belcher; Rosalinda Sorrentino; Jasmine Anandarajah; Mark Fleet; Shiranee Sriskandan; Jane A Mitchell
Journal:  Br J Pharmacol       Date:  2006-06-19       Impact factor: 8.739

Review 4.  Role of lipoteichoic acid in infection and inflammation.

Authors:  Isaac Ginsburg
Journal:  Lancet Infect Dis       Date:  2002-03       Impact factor: 25.071

5.  Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.

Authors:  Nicolas W J Schröder; Siegfried Morath; Christian Alexander; Lutz Hamann; Thomas Hartung; Ulrich Zähringer; Ulf B Göbel; Joerg R Weber; Ralf R Schumann
Journal:  J Biol Chem       Date:  2003-02-19       Impact factor: 5.157

6.  Hemoglobin increases mortality from bacterial endotoxin.

Authors:  D Su; R I Roth; M Yoshida; J Levin
Journal:  Infect Immun       Date:  1997-04       Impact factor: 3.441

7.  Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation.

Authors:  B Opitz; N W Schröder; I Spreitzer; K S Michelsen; C J Kirschning; W Hallatschek; U Zähringer; T Hartung; U B Göbel; R R Schumann
Journal:  J Biol Chem       Date:  2001-04-02       Impact factor: 5.157

8.  Synergistic toxicity of endotoxin and hemoglobin.

Authors:  C T White; A J Murray; D J Smith; J R Greene; R B Bolin
Journal:  J Lab Clin Med       Date:  1986-08

9.  Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation.

Authors:  Hyun-Ku Lee; Stefan Dunzendorfer; Peter S Tobias
Journal:  J Biol Chem       Date:  2003-12-29       Impact factor: 5.157

10.  Streptolysin S activation by lipoteichoic acid.

Authors:  T S Theodore; G B Calandra
Journal:  Infect Immun       Date:  1981-07       Impact factor: 3.441
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  5 in total

1.  Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin.

Authors:  Tian Lin; Young Ho Kwak; Fatima Sammy; Ping He; Sujatha Thundivalappil; Guangjie Sun; Wei Chao; H Shaw Warren
Journal:  J Infect Dis       Date:  2010-08-15       Impact factor: 5.226

Review 2.  A perspective on the role of extracellular hemoglobin on the innate immune system.

Authors:  Sae Kyung Lee; Jeak Ling Ding
Journal:  DNA Cell Biol       Date:  2012-12-18       Impact factor: 3.311

3.  Lipoteichoic acid synergizes with glycosphingolipids to potently stimulate secretion of interleukin-6 from human blood cells.

Authors:  Shiri Meron-Sudai; Ariella Matityahou; Yona Keisari; Kathleen H Cox; David L Hasty; Itzhak Ofek
Journal:  Clin Vaccine Immunol       Date:  2008-07-16

4.  A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.

Authors:  Timothy E Sweeney; Hagir B Suliman; John W Hollingsworth; Karen E Welty-Wolf; Claude A Piantadosi
Journal:  PLoS One       Date:  2011-09-26       Impact factor: 3.240

5.  Pathways involved in the synergistic activation of macrophages by lipoteichoic acid and hemoglobin.

Authors:  Kathleen H Cox; Michelle E Cox; Virginia Woo-Rasberry; David L Hasty
Journal:  PLoS One       Date:  2012-10-10       Impact factor: 3.240
  5 in total

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