BACKGROUND: Morbidly obese individuals (ie, body mass index [BMI], > or = 40 kg/m2) may have a pulmonary gas exchange impairment due to the large fat mass surrounding their abdomen. PURPOSES: To examine the effect of the waist-to-hip (W/H) ratio on pulmonary gas exchange in the morbidly obese. METHODS: Twenty-five morbidly obese individuals (mean [+/- SD] age, 39 +/- 10 years; mean BMI, 49 +/- 7 kg/m2; mean body fat, 50 +/- 6%; mean waist circumference, 135 +/- 15 cm; mean W/H ratio, 0.97 +/- 0.11) scheduled for bariatric surgery were recruited. Arterial blood was sampled in duplicate after 5 min of rest sitting upright. RESULTS: The mean PaO2 at rest was 88 +/- 7 mm Hg (range, 72 to 108 mm Hg), the alveolar-arterial oxygen pressure difference (P[A-a]O2) was 19 +/- 9 mm Hg (range, 1 to 37 mm Hg), and the PacO2 was 38 +/- 3 mm Hg (range, 32 to 44 mm Hg). Linear regression showed that 32% and 36%, respectively, of the variance in the P(A-a)O2 and PaO2 were explained by the W/H ratio (p < 0.004 for both). As well, 20% of the variance in PacO2 was explained by the W/H ratio (p = 0.02). Men had larger W/H ratios (p < 0.01) and poorer gas exchange (p = 0.06) compared to women (mean difference: PaO2, -7 mm Hg; P[A-a]O2, 6 mm Hg). CONCLUSION: Morbidly obese men showed a trend to have poorer pulmonary gas exchange compared to morbidly obese women, and a significant part of the blood gas status in these patients is associated with the W/H ratio.
BACKGROUND: Morbidly obese individuals (ie, body mass index [BMI], > or = 40 kg/m2) may have a pulmonary gas exchange impairment due to the large fat mass surrounding their abdomen. PURPOSES: To examine the effect of the waist-to-hip (W/H) ratio on pulmonary gas exchange in the morbidly obese. METHODS: Twenty-five morbidly obese individuals (mean [+/- SD] age, 39 +/- 10 years; mean BMI, 49 +/- 7 kg/m2; mean body fat, 50 +/- 6%; mean waist circumference, 135 +/- 15 cm; mean W/H ratio, 0.97 +/- 0.11) scheduled for bariatric surgery were recruited. Arterial blood was sampled in duplicate after 5 min of rest sitting upright. RESULTS: The mean PaO2 at rest was 88 +/- 7 mm Hg (range, 72 to 108 mm Hg), the alveolar-arterial oxygen pressure difference (P[A-a]O2) was 19 +/- 9 mm Hg (range, 1 to 37 mm Hg), and the PacO2 was 38 +/- 3 mm Hg (range, 32 to 44 mm Hg). Linear regression showed that 32% and 36%, respectively, of the variance in the P(A-a)O2 and PaO2 were explained by the W/H ratio (p < 0.004 for both). As well, 20% of the variance in PacO2 was explained by the W/H ratio (p = 0.02). Men had larger W/H ratios (p < 0.01) and poorer gas exchange (p = 0.06) compared to women (mean difference: PaO2, -7 mm Hg; P[A-a]O2, 6 mm Hg). CONCLUSION: Morbidly obesemen showed a trend to have poorer pulmonary gas exchange compared to morbidly obesewomen, and a significant part of the blood gas status in these patients is associated with the W/H ratio.
Authors: Thomas E Lohmeier; Radu Iliescu; Ionut Tudorancea; Radu Cazan; Adam W Cates; Dimitrios Georgakopoulos; Eric D Irwin Journal: Hypertension Date: 2016-05-09 Impact factor: 10.190
Authors: Young Sik Park; Hyuk Tae Kwon; Seung-Sik Hwang; Seung Ho Choi; Young Min Cho; Jinwoo Lee; Jae-Joon Yim Journal: J Korean Med Sci Date: 2011-05-18 Impact factor: 2.153
Authors: Anne-Marie Gabrielsen; May Brit Lund; Johny Kongerud; Karl Erik Viken; Jo Røislien; Jøran Hjelmesæth Journal: Obes Surg Date: 2011-04 Impact factor: 4.129