| Literature DB >> 17296187 |
Jeff G Wang1, Richard A Anderson, George M Graham, Micheline C Chu, Mark V Sauer, Michael M Guarnaccia, Rogerio A Lobo.
Abstract
Cinnamon extract has been shown to reduce insulin resistance in in vitro and in vivo studies by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway and thus potentiating insulin action. Fifteen women with polycystic ovary syndrome (PCOS) were randomized to daily oral cinnamon and placebo for 8 weeks. Comparisons of post-treatment to baseline insulin sensitivity indices using fasting and 2-hour oral glucose tolerance tests showed significant reductions in insulin resistance in the cinnamon group but not in the placebo group. A larger trial is needed to confirm the findings of this pilot study and to evaluate the effect of cinnamon extract on menstrual cyclicity.Entities:
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Year: 2007 PMID： 17296187 DOI： 10.1016/j.fertnstert.2006.11.082
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329