Literature DB >> 17296158

Myxoma virus in the European rabbit: interactions between the virus and its susceptible host.

Marianne M Stanford1, Steven J Werden, Grant McFadden.   

Abstract

Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.

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Year:  2007        PMID： 17296158     DOI： 10.1051/vetres:2006054

Source DB:  PubMed          Journal:  Vet Res        ISSN： 0928-4249            Impact factor:   3.683


  41 in total

1.  Myxoma virus: propagation, purification, quantification, and storage.

Authors:  Sherin E Smallwood; Masmudur M Rahman; Dorothy W Smith; Grant McFadden
Journal:  Curr Protoc Microbiol       Date:  2010-05

2.  Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways.

Authors:  Masmudur M Rahman; Grant McFadden
Journal:  J Virol       Date:  2011-09-28       Impact factor: 5.103

3.  Infection of nonhost species dendritic cells in vitro with an attenuated myxoma virus induces gene expression that predicts its efficacy as a vaccine vector.

Authors:  S Top; E Foulon; B Pignolet; M Deplanche; C Caubet; C Tasca; S Bertagnoli; G Meyer; G Foucras
Journal:  J Virol       Date:  2011-08-10       Impact factor: 5.103

4.  Myxoma and vaccinia viruses exploit different mechanisms to enter and infect human cancer cells.

Authors:  Nancy Y Villa; Eric Bartee; Mohamed R Mohamed; Masmudur M Rahman; John W Barrett; Grant McFadden
Journal:  Virology       Date:  2010-03-24       Impact factor: 3.616

5.  Molecular methods in detection and epidemiologic studies of rabbit and hare viruses: a review.

Authors:  Ewa Kwit; Artur Rzeżutka
Journal:  J Vet Diagn Invest       Date:  2019-05-25       Impact factor: 1.279

6.  Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo.

Authors:  Marianne M Stanford; Mae Shaban; John W Barrett; Steven J Werden; Philippe-Alexandre Gilbert; Joe Bondy-Denomy; Lisa Mackenzie; Kevin C Graham; Ann F Chambers; Grant McFadden
Journal:  Mol Ther       Date:  2007-11-13       Impact factor: 11.454

7.  The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells.

Authors:  Steven J Werden; Jerry Lanchbury; Donna Shattuck; Chris Neff; Max Dufford; Grant McFadden
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103

8.  M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit.

Authors:  Sophie Blanié; Jérémy Mortier; Maxence Delverdier; Stéphane Bertagnoli; Christelle Camus-Bouclainville
Journal:  Vet Res       Date:  2008-11-19       Impact factor: 3.683

9.  Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013.

Authors:  Masmudur M Rahman; Mohamed R Mohamed; Manbok Kim; Sherin Smallwood; Grant McFadden
Journal:  PLoS Pathog       Date:  2009-10-23       Impact factor: 6.823

10.  Detection of myxoma viruses encoding a defective M135R gene from clinical cases of myxomatosis; possible implications for the role of the M135R protein as a virulence factor.

Authors:  Graham J Belsham; Charlotta Polacek; Solvej Ø Breum; Lars E Larsen; Anette Bøtner
Journal:  Virol J       Date:  2010-01-16       Impact factor: 4.099
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