Gastrocystoplasty in dogs: an ulcerating effect of acid urine.

Six dogs underwent bladder augmentation using an isolated flap of the body of the stomach after a supratrigonal cystectomy. Each dog was followed for six months with periodic determinations of urine pH, blood chemistry, cystometry and cystography. Postoperatively, urine pH decreased markedly after a meal in most dogs. No persistent hypergastrinemia was found. Autopsy showed that histological erosions developed in the bladder remnant in five dogs, and an ulcer in the bladder remnant in one dog. These results indicate that when an isolated, vagally denervated gastric segment is incorporated into the bladder, acid secretion from the segment may ulcerate the bladder.